Nolycin, 400 mg 20 pcs

A broad-spectrum antimicrobial of the group of fluoroquinolones.

It has a bactericidal effect. It affects the bacterial enzyme DNA-gyraza, which provides superspiralization and thus stability of bacterial DNA. Destabilization of the DNA chain leads to the death of the bacteria. It has a broad spectrum of antibacterial action.

The drug is sensitive to Staphylococcus aureus (including strains of Staphylococcus spp. resistant to methicillin), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp, Hafhia alvei, Proteus spp. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp.

Different sensitivity to the drug has: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of antimicrobial action is about 12 hours.

Indications

urinary tract infections,
gonorrhea,
chronic prostatitis,
intestinal infections.

Pharmacological effect

Antimicrobial drug of the fluoroquinolone group with a broad spectrum of action.

Has a bactericidal effect. It affects the bacterial enzyme DNA gyrase, which ensures supercoiling and, thus, stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. Has a wide spectrum of antibacterial action.

Staphylococcus aureus (including strains of Staphylococcus spp., resistant to methicillin), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Hafhia alvei, Proteus spp. are sensitive to the drug. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp., Legionella spp.

The following have different sensitivity to the drug: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of the antimicrobial effect is about 12 hours.

Special instructions

It should be used with caution in patients with epilepsy, with severe renal and liver dysfunction. During treatment with Nolitsin, it is necessary to receive a sufficient amount of fluid and sunbathing is not recommended.

It should not be prescribed simultaneously with antacid drugs; the interval between the use of these drugs should be at least 2 hours. If pain in the joints and ligaments occurs, treatment with Nolitsin should be discontinued. Do not take simultaneously with antiarrhythmic drugs of classes I and III, tricyclic antidepressants.

Active ingredient

Norfloxacin

Composition

1 film-coated tablet contains:

CORE:

Active substance:

norfloxacin – 400 mg.

Excipients:

povidone,

sodium carboxymethyl starch,

microcrystalline cellulose,

colloidal silicon dioxide,

anhydrous,

magnesium stearate,

purified water (for hydration).

SHELL:

hapromellose, talc, titanium dioxide, sunset yellow dye, E110 (dispersed yellow dye, E110), propylene glycol.

Contraindications

pregnancy and lactation; childhood and adolescence (up to 18 years); hypersensitivity to norfloxacin, drug components and other quinolones; deficiency of glucose-6-phosphate dehydrogenase; With caution: epileptic syndrome, cerebral atherosclerosis, cerebrovascular accident, epilepsy, renal/liver failure, allergic reaction to acetylsalicylic acid.

Side Effects

nausea, heartburn, diarrhea, abdominal pain
headache, dizziness, feeling tired
sleep disorders, irritability, anxiety
skin rash.

Interaction

With the simultaneous use of norfloxacin and theophylline, the concentration of theophylline in the blood plasma should be monitored and its dose adjusted, since norfloxacin reduces the clearance of theophylline by 25%, and the development of corresponding undesirable side effects may be observed. Reduces the effect of nitrofurans.

Norfloxacin may enhance the therapeutic effect of cyclosporine and warfarin; in some cases, when using norfloxacin with cyclosporine, an increase in serum creatinine concentration was observed, therefore, monitoring of this indicator is necessary in such patients.

The simultaneous use of norfloxacin and antacids containing aluminum or magnesium hydroxide, as well as drugs containing iron, zinc, sucralfate, reduces the absorption of norfloxacin (the interval between their administration should be at least 2 hours).

Concomitant use with drugs that lower the seizure threshold can lead to the development of epileptiform seizures.

Concomitant use with glucocorticosteroids may increase the risk of tendonitis or tendon rupture. Norfloxacin may enhance the therapeutic effect of hypoglycemic drugs (sulfonylurea derivatives). Concomitant use of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as when administered simultaneously with barbiturates and other drugs for general anesthesia, heart rate, blood pressure and ECG readings should be monitored.

Overdose

In case of overdose, the following symptoms may occur: diarrhea, nausea, vomiting. In severe cases: convulsions, dizziness, drowsiness, “cold” sweat, puffy face without changing the main hemodynamic indications.

Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. Requires examination and observation in a hospital for several days. There is no specific antidote.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life

5 years

Manufacturer

KRKA-RUS/KRKA, Russia