Nolycin, 400 mg 20 pcs

A broad-spectrum antimicrobial of the group of fluoroquinolones.

It has a bactericidal effect. It affects the bacterial enzyme DNA-gyraza, which provides superspiralization and thus stability of bacterial DNA. Destabilization of the DNA chain leads to the death of the bacteria. It has a broad spectrum of antibacterial action.

The drug is sensitive to Staphylococcus aureus (including strains of Staphylococcus spp. resistant to methicillin), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp, Hafhia alvei, Proteus spp. (indole-positive and indole-negative strains), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae, Chlamydia spp.

Different sensitivity to the drug has: Enterococcus faecalis, Streptococcus spp. (Streptococcus pyogenes, Streptococcus pneumoniae and Streptococcus viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp, Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

The duration of antimicrobial action is about 12 hours.

Indications

Active ingredient

Composition

1 film-coated tablet contains:

Nucleus:

Active substance:

norfloxacin – 400 mg.

Associates:

povidone,

sodium carboxymethyl starch,

microcrystalline cellulose,

colloidal silicon dioxide,

anhydrous,

magnesium stearate,

purified water (for hydration).

Wrapper:

Hapromellose, talc, titanium dioxide, sunset yellow dye, E110 (dispersed yellow dye, E110), propylene glycol.

How to take, the dosage

A single oral dose of Nolitsin is 400-800 mg, the frequency of use is 1-2 times a day.

The duration of treatment is 7-14 days. In gonorrhea the course of treatment is 3-5 days, in chronic prostatitis 4-6 weeks.

Interaction

In concomitant use of norfloxacin and theophylline, plasma concentrations of theophylline should be monitored and the dose adjusted, since norfloxacin reduces the clearance of theophylline by 25%, and the development of related undesirable side effects may be observed. Reduces the effect of nitrofurans.

Norfloxacin may increase therapeutic effects of cyclosporine and warfarin; in some cases when using norfloxacin with cyclosporine an increase in serum creatinine concentration was observed; therefore, in these patients it is necessary to monitor this parameter.

The simultaneous use of norfloxacin and antacids containing aluminum or magnesium hydroxide, as well as agents containing iron, zinc, sucralfate, reduces absorption of norfloxacin (interval between their intake should be at least 2 hours).

The concomitant use with drugs that lower the seizure threshold may lead to epileptiform seizures.

Simultaneous use with glucocorticosteroids may contribute to an increased risk of tendinitis or tendon rupture. Norfloxacin may increase the therapeutic effect of hypoglycemic drugs (sulfonylurea derivatives). Concomitant use of norfloxacin with drugs that have the potential ability to lower blood pressure may cause a sharp decrease in blood pressure. Therefore, in such cases, as well as when concomitantly administered with barbiturates and other medicinal agents for general anesthesia heart rate, blood pressure and ECG parameters should be controlled.

Special Instructions

We should use with caution in patients with epilepsy, with marked renal and hepatic dysfunction. During treatment with the drug Nolycin it is necessary to get enough fluids and it is not recommended to sunbathe.

Do not use simultaneously with antacids, the interval between the use of these drugs should be at least 2 hours. In case of pain in joints and ligaments – treatment with Nolycin should be stopped. Do not take simultaneously with antiarrhythmic drugs of I and III classes, tricyclic antidepressants.

Contraindications

Pregnancy and lactation; childhood and adolescence (under 18 years); hypersensitivity to norfloxacin, drug components and other quinolones; glucose-6-phosphate dehydrogenase deficiency; Caution: Epileptic syndrome, cerebral vascular atherosclerosis, impaired cerebral circulation, epilepsy, renal/liver failure, presence of allergic reaction to acetylsalicylic acid.

Side effects

Overdose

In case of overdose, the following symptoms may occur: diarrhea, nausea, vomiting. In severe cases: convulsions, dizziness, drowsiness, “cold” sweat, puffy face with no change in the basic hemodynamic indications.

Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. Examination and observation in hospital for several days is required. There is no specific antidote.

Similarities