Neupilept, 100 mg/ml 100 ml

Indications

Active ingredient

Composition

Active ingredient:
citicoline sodium (in terms of citicoline) 500 mg
Excipients:
hydrochloric acid concentrated
or
sodium hydroxide to pH 6.5-7.5
water for injection to 4 ml

.

How to take, the dosage

Recommended dosing regimen
Acute period of ischemic stroke and traumatic brain injury (TBI):
1000 mg citicoline every 12 hours from the first day after diagnosis, treatment duration
at least 6 weeks.
Maximum daily dose – 2000 mg.

Restorative period of ischemic and hemorrhagic strokes, restorative
period of CMP, cognitive and behavioral disorders in degenerative and vascular
brain diseases:
Administered v/v or intram 500-2000 mg citicoline daily. Dosage and duration of treatment depend on the severity of the disease symptoms.
Elderly patients
When administering NEIPILEPT® for elderly patients no dose adjustment is required.
The drug should be used immediately after opening the ampoule.
NEUPYLEPT® is given intramuscularly, intravenously by jetting (slowly over 3-5 minutes depending on the dose prescribed) or dropwise (infusion rate – 40-60 drops per
minute).
The intravenous (IV) route of administration is preferable to the intramuscular (IV) route. When administered intravenously, avoid repeated administration to the same site.
NEUPILEPT® is compatible with all types of intravenous isotonic solutions and
dextrose solutions.

Special Instructions

Intravenous NeUPILEPT® is administered slowly (3-5 minutes depending on the dose).
In intravenous drip infusion, the infusion rate should be 40-60 drops per minute.
In case of persistent intracranial hemorrhage it is recommended not to exceed the dose
of NEUPILEPT® 1000 mg per day, the drug is administered intravenously by drop infusion at the rate of 30 drops per minute.
Influence on the ability to drive vehicles, mechanisms
During the use of the drug caution should be exercised while driving a vehicle and engaging in other potentially dangerous activities that require
increased concentration and rapid psychomotor reactions.

Contraindications

– Hypersensitivity to any of the drug components;
– Do not prescribe to patients with severe vagotonia (high tone of parasympathetic nervous system);
– Due to lack of sufficient clinical data it is not recommended to use in children
under 18 years.

Side effects

Side effects are grouped by frequency of occurrence: very frequently (> 1/10), frequently
(≥ 1/100 to < 1/10), infrequently (≥ 1/1000 to < 1/100), rarely (≥ 1/10000 to < 1/1000), very rarely
(< 1/10000), frequency not determined.
Very rare (including individual cases): Allergic reactions (rash, skin itching,
anaphylactic shock), headache, dizziness, fever, tremor, nausea,
vomiting, diarrhea, hallucinations, edema, shortness of breath, insomnia, agitation, decreased appetite,
numbness in paralyzed limbs, changes in liver enzyme activity. In
some cases, citicoline may stimulate the parasympathetic system, and
have short-term changes in blood pressure.
If any of the side effects listed in the instructions are aggravated or you notice
any other side effects not specified in the instructions, tell your doctor.

Overdose

Pregnancy use

There are insufficient data on the use of citicoline in pregnant women. Although no adverse effects were found in
animal studies, during pregnancy
citicoline is prescribed only when the expected benefit to the mother exceeds
the potential risk to the fetus.
When using citicoline during lactation women should stop breast
feeding, since there are no data on the excretion of citicoline with the breast milk.

Similarities