Nemozol, 400 mg

Nemozolol is an anthelminthic agent effective in mono- and polyinvasions.

Selectively inhibits polymerization of beta-tubulin, disrupts activity of microtubular system of cells of intestinal canal of helminthes; inhibits utilization of glucose, blocks movement of secretory granules and other organelles in muscle cells of roundworms, causing their death.

It is especially effective against larval forms of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis

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Indications

Neurocysticercosis caused by the larval form of the pork tapeworm (Taenia solium).
Echinococcosis of the liver, lungs, peritoneum, caused by the larval form of the canine tapeworm (Echinococcus granulosus).
Nematodes: ascariasis, trichuriasis, hookworm disease, enterobiasis, strongyloidiasis, opisthorchiasis, giardiasis, microsporidiosis.
Mixed helminthiases.

Pharmacological effect

Nemozol is an anthelmintic agent that is effective against mono- and polyinfestations.

Selectively inhibits the polymerization of beta-tubulin, disrupts the activity of the microtubular system of the cells of the intestinal canal of helminths; suppresses the utilization of glucose, blocks the movement of secretory granules and other organelles in the muscle cells of roundworms, causing their death.

Particularly effective against larval forms of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis

Special instructions

It is necessary to discontinue therapy if leukopenia develops.

In case of neurocysticercosis with eye damage, before starting treatment, it is necessary to examine the retina (risk of worsening its pathology).

Women of reproductive age are tested to determine if they are not pregnant before starting treatment.

Reliable contraception is required during therapy.

Patients receiving high doses should be closely monitored, with constant monitoring of blood status and liver function.

Active ingredient

Albendazole

Composition

1 tablet contains:

Active substance: albendazole 400 mg;

Excipients:

corn starch,

sodium lauryl sulfate,

povidone-30,

methylparaben,

propylparaben,

citric acid,

gelatin,

purified talc,

sodium starch glycolate,

colloidal silicon dioxide,

magnesium stearate,

aspartame,

pineapple flavoring,

mint aroma.

Pregnancy

The drug albendazole is contraindicated during pregnancy and breastfeeding.

Contraindications

Hypersensitivity, pregnancy, lactation, childhood (up to 6 years – safety has not been determined).

With caution: suppression of bone marrow hematopoiesis, liver failure, liver cirrhosis, retinal pathology.

Side Effects

From the digestive system: abdominal pain, nausea, vomiting, increased activity of liver transaminases.

From the nervous system: headache, dizziness, meningeal symptoms.

From the hematopoietic organs: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia. Allergic reactions: skin rash, itching.

Other: hyperthermia, increased blood pressure, renal dysfunction, alopecia, acute renal failure.

Interaction

Concomitant use of albendazole with iraziquantel, dexamethasone and cimetidine may increase the concentration of albendazole sulfoxide in the blood.

Overdose

Treatment: gastric lavage, activated carbon. If necessary, carry out symptomatic therapy.

Storage conditions

In a dry place, protected from light, at a temperature below 25 °C

Shelf life

3 years

Manufacturer

Ipka Laboratories Limited, India