Nemozol, 400 mg

Nemozolol is an anthelminthic agent effective in mono- and polyinvasions.

Selectively inhibits polymerization of beta-tubulin, disrupts activity of microtubular system of cells of intestinal canal of helminthes; inhibits utilization of glucose, blocks movement of secretory granules and other organelles in muscle cells of roundworms, causing their death.

It is especially effective against larval forms of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis

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Indications

Active ingredient

Composition

1 tablet contains:

The active ingredient: albendazole 400 mg;

Associates:

Corn starch,

sodium lauryl sulfate,

povidone-30,

methylparaben,

propylparaben,

citric acid,

gelatin,

talcum powder,

sodium starch glycolate,

silica colloidal dioxide,

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magnesium stearate,

aspartame,

pineapple flavoring,

mint flavor.

How to take, the dosage

Nemozolol is administered orally, with meals or after meals, the tablets are not chewed and are washed down with water. The use of laxatives and a special diet are not required. It is recommended to treat all members of the family at the same time.

The dose of Nemozole is set individually, depending on the type of helminth and body weight of the patient.

Nemozole administration in children under 2 years old

Cysticercosis of the brain (neurocysticercosis): 15 mg/kg/day for 8 days, repeated if necessary.

Ankylostomidosis, enterobiasis, ascariasis: 200 mg once, repeated in 3 weeks if necessary.

Strongyloidiasis and cestodiasis: 200 mg once daily for 3 days, if necessary it is repeated in 3 weeks.

Nemozole administration in children over 2 years old and adults

Neurocysticercosis and echinococcosis: Patients with a body weight of 60 kg or more Nemozolol is prescribed at 400 mg 2 times a day, with a body weight less than 60 kg the dose is set at the rate of 15 mg/kg/day, divided into 2 doses; the maximum daily dose is 800 mg; treatment course for neurocysticercosis is 8-30 days; for echinococcosis – 3 cycles of 28 days with a 14-day interval between cycles.

Ascaridosis, trichocephaliasis, enterobiasis and ankylostomidosis: 400 mg once, repeated in 3 weeks if necessary.

Strongyloidiasis and cestodiasis: 400 mg once daily for 3 days, repeated in 3 weeks if necessary.

Lambliosis: 400 mg once daily for 3 days or at the rate of 10-15 mg/kg once daily for 5-7 days.

Toxocarosis: to adults and children over 14 years old with body weight over 60 kg Nemozolol is used in a single dose of 400 mg, in those with body weight less than 60 kg – 200 mg, in children under 14 years the dose is 10 mg/kg, 2 times a day and the therapy duration is 7-14 days.

Interaction

Special Instructions

The therapy should be discontinued if leukopenia develops.

In neurocysticercosis with ocular lesions the retina should be examined before starting treatment (risk of exacerbating its pathology).

Women of reproductive age are tested for absence of pregnancy before starting treatment.

With therapy reliable contraception is mandatory.

Patients receiving high doses should be closely monitored, with constant monitoring of blood and liver function.

Contraindications

Hypersensitivity, pregnancy, lactation, childhood (under 6 years – safety not determined).

With caution: inhibition of medullary hematopoiesis, hepatic failure, cirrhosis, retinal pathology.

Side effects

Digestive system disorders: abdominal pain, nausea, vomiting, increased activity of “liver” transaminases.

Nervous system disorders: headache, dizziness, meningeal symptoms.

Hematopoietic disorders: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia. Allergic reactions: skin rash, itching.

Others:Hyperthermia, increased BP, impaired renal function, alopecia, acute renal failure.

Overdose

Treatment: gastric lavage, activated charcoal. If necessary, symptomatic therapy is carried out.

Pregnancy use

Similarities