Nazik, spray 0.05 mg+5 mg/dose 10 ml

Nasik is a combined nasal drug for topical use, containing Xylometazoline and Dexpanthenol.

Xylometazoline refers to a group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes narrowing of blood vessels of nasal mucosa, restores nasal passages, facilitates nasal breathing. The action of the drug usually starts within a few minutes after application and lasts up to 10 hours.

Dexpanthenol is a B vitamin and a derivative of pantothenic acid. Dexpanthenol is converted in the body into pantothenic acid, which is part of coenzyme A and is involved in the processes of acetylation, carbohydrate and
Fat metabolism, synthesis of acetylcholine, corticosteroids, porphyrins; stimulates skin and mucous membrane regeneration, normalizes cell metabolism, accelerates mitosis and increases the strength of collagen fibers.

It has a regenerating, metabolic and mild anti-inflammatory effect.

PHARMACOKINETICS

Xylometazoline is virtually unabsorbed by topical administration, with plasma concentrations so low that they
cannot be determined by modern analytical methods.

Dexpanthenol when applied topically is rapidly absorbed by the skin and is converted to pantothenic acid and binds to plasma proteins (mainly beta-globulin and albumin).

The concentration in blood is 0.5-1 mg/l, in serum 100 µg/l. Pantothenic acid is not metabolized in the body (except for its inclusion in the Co-A) and excreted unchanged.

Indications

acute respiratory diseases with symptoms of rhinitis;
acute allergic rhinitis;
vasomotor rhinitis;
sinusitis;
otitis media (as part of combination therapy to reduce swelling of the nasopharyngeal mucosa);
to facilitate rhinoscopy;
to restore impaired nasal breathing after surgical interventions in the nasal cavity.

Pharmacological effect

Nazik is a combined nasal preparation for topical use containing Xylometazoline and Dexpanthenol.

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes constriction of the blood vessels of the nasal mucosa, restores the patency of the nasal passages, and facilitates nasal breathing. The effect of the drug usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol is a B vitamin and is a derivative of pantothenic acid. Dexpanthenol is converted in the body into pantothenic acid, which is a component of coenzyme A and is involved in the processes of acetylation, carbohydrate and
fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins; stimulates regeneration of skin, mucous membranes
membranes, normalizes cellular metabolism, accelerates mitosis and increases the strength of collagen fibers.

It has a regenerating, metabolic and mild anti-inflammatory effect.

PHARMACOKINETICS

Xylometazoline is practically not absorbed when applied topically; plasma concentrations are so low that they are
impossible to determine using modern analytical methods.

When applied topically, dexpanthenol is quickly absorbed by the skin and converted into pantothenic acid and binds to plasma proteins (mainly beta-globulin and albumin).

Its concentration in the blood is 0.5-1 mg/l, in the blood serum – 100 μg/l. Pantothenic acid is not metabolized in the body (except for inclusion in Co-A) and is excreted unchanged.

Special instructions

Before use, it is necessary to clean the nasal passages. Should not be used for more than 7 days. The duration of use of the drug in children is determined after consultation with a doctor.

Impact on the ability to drive vehicles and operate machinery

During the period of use of the drug, caution should be exercised when performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Xylometazoline, [Dexpanthenol]

Composition

Active ingredients:

xylometazoline hydrochloride 0.05 mg,

dexpanthenol 5 mg;

Excipients:

benzalkonium chloride (in the form of 50% solution) 0.04 mg,

potassium dihydrogen phosphate 0.853 mg,

sodium hydrogen phosphate dodecahydrate 0.027 mg,

purified water 94.03 mg.

Pregnancy

Considering that there is no data on the reproductive toxicity of the drug, its use during pregnancy and lactation is not recommended.

Contraindications

hypersensitivity to the components of the drug;
arterial hypertension;
tachycardia;
severe atherosclerosis;
hyperthyroidism;
glaucoma;
atrophic rhinitis;
surgical interventions on the meninges (history);
dry rhinitis;
children under 2 years of age.

With caution: diabetes mellitus, pheochromocytoma.

Side Effects

With frequent and/or prolonged use – irritation and/or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion, allergic reactions, swelling of the nasal mucosa, vomiting, headache, dry rhinitis, palpitations, increased blood pressure, insomnia, blurred vision, depression (with long-term use of high doses).

Interaction

Concomitant use of MAO inhibitors and tricyclic antidepressants may lead to an increase in blood pressure due to the effects of these drugs on the cardiovascular system.

Overdose

Symptoms: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, cardiac arrhythmias, cardiac arrest, hypertension, pulmonary edema, respiratory dysfunction, hallucinations. Patients may also experience symptoms of central nervous system depression, including drowsiness, decreased body temperature, bradycardia, shock, respiratory arrest, and coma.

Treatment. The use of activated carbon, gastric lavage, oxygen ventilation. To lower blood pressure, 5 mg of phentolamine in 0.9% sodium chloride solution is prescribed by slow intravenous administration or 100 mg of phentolamine orally. Vasoconstrictor drugs are contraindicated. If necessary, antipyretic and anticonvulsants are used.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Manufacturer

Klosterfrau Berlin GmbH, Germany