Naxogene, tablets 500 mg 6 pcs

Naxogene^® is a chemotherapeutic drug showing activity against Trichomonas vaginalis and other protozoa (including Giardia intestinalis and Entamoeba histolytica) as well as against anaerobic bacteria, namely Bacteroides and Gardnerella vaginalis.

The minimum trichomonacid concentration ranges from 0.3 to 3 µg/ml.

Pharmacokinetics

Naxogene^® is well absorbed after oral administration. After three doses of 1 g nimorazole every 12 hours, the drug’s blood concentration reaches 16 mcg/mL 3 hours after the first dose, 28 mcg/mL by the 25th hour, and 7.5 mcg/mL after the last dose.

Naxogene^® is excreted primarily through the kidneys; concentrations of nimorazole and its active metabolites in urine and vaginal secretion significantly exceed trichomonacid concentrations. After three doses of Naxojin^® at a dose of 1 g every 12 h, the concentration of nimorazole in vaginal secretion, measured at 24, 48 and 72 h, was 129 µg/g, 95 µg/g and 4 µg/g, respectively.

Indications

Trichomoniasis, Vaginitis, Amebiasis and Giardiasis

Infections caused by Trichomonas vaginalis.

Active ingredient

Nimorazole

Composition

Active ingredient:

Nimorazole 500 mg;

Assisted substances:

Corn starch;

Methylcellulose;

MCC;

Stearic acid;

How to take, the dosage

Orally, after meals.

Trichomoniasis: adults, 2 g once or 3 doses of 1 g every 12 hours (e.g., morning, evening and next morning) or 250 mg 2 times daily for 6 days. In children, 15 mg/kg per day divided into 3 doses for 5-7 days.

Amoebiasis: adults – 500 mg 2 times a day for 5-10 days; children – 20 mg/kg per day divided into 2 doses for 5-10 days.

Lambliasis: adults – 500 mg 2 times a day for 5-7 days; children – 15 mg/kg per day, divided into 2 doses for 5-7 days.

Infection caused by Gardnerella vaginalis: adults – 500 mg 2 times a day for 7 days or 2 g once.

Acute ulcerative and necrotizing gingivitis (Wincet’s gingivitis): adults – 500 mg 2 times a day for 2 days.

Special Instructions

Symptoms of inflammation (itching, watery discharge, etc.) may persist for several days after the course ends.

Contraindications

Hypersensitivity, CNS disorders, active neurological diseases.

Side effects

Nausea, heartburn, dizziness, drowsiness, rash.