Natecal D3, tablets 60 pcs

Natecal D3 is a combined drug that regulates calcium and phosphorus metabolism in the body.

Limits resorption (resorption) and increases bone density by replenishing the lack of calcium and vitamin D₃ in the body.

Vitamin D₃ increases absorption of calcium in the gastrointestinal tract and its binding in bone tissue.

The use of calcium and vitamin D₃ prevents increased production of parathyroid hormone (which is a stimulant of increased bone resorption (leaching of calcium from bones).

Indications

Used as a therapeutic and prophylactic agent:

for the prevention and complex therapy of osteoporosis;
replenishment of calcium and vitamin D3 deficiency in elderly people.

Pharmacological effect

Natekal D3 is a combination drug that regulates the metabolism of calcium and phosphorus in the body.

Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body.

Vitamin D3 increases calcium absorption in the gastrointestinal tract and its binding in bone tissue.

The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone (which is a stimulator of increased bone resorption (leaching of calcium from bones).

Special instructions

During treatment with the drug, it is necessary to constantly monitor the excretion of calcium in the urine and the concentration of calcium and creatinine in the blood plasma. The dose should be reduced or treatment should be temporarily discontinued if serum calcium or creatinine concentrations increase, or if urinary calcium levels exceed 7.5 mmol/24 hours (300 mg/24 hours). To avoid overdose, additional intake of vitamin D3 from other sources must be taken into account. Do not use simultaneously with vitamin-mineral complexes containing calcium and vitamin D3. In older people, the need for calcium is 1.5 g/day, for vitamin D3 – 500-1000 IU/day. To prevent decreased absorption of a bisphosphonate or sodium fluoride, it is recommended to take NATEKAL D3 no earlier than 3 hours after taking it. Corticosteroids reduce the absorption of calcium, so treatment with corticosteroids may require an increase in the dose of NATEKAL D3.

Active ingredient

Calcium carbonate, Colecalciferol

Composition

One tablet contains:
Active ingredients: calcium carbonate – 1500 mg (equivalent to Ca2+ – 600 mg), cholecalciferol – 400 IU (equivalent to dry vitamin D3 * – 4 mg).
Excipients: maltodextrin, anhydrous citric acid, low molecular weight hydroxypropyl cellulose, lactose monohydrate, aspartame, orange flavor, stearic acid;
* alpha-tocopherol acetate, hydrogenated soybean oil, gelatin, sucrose, corn starch.

Pregnancy

Perhaps, but not more than 1500 mg of calcium and 600 IU of vitamin D3 per day.

Contraindications

hypersensitivity to one of the components of the drug (including peanuts or soy);
intolerance to certain types of sugars: lactose, sucrose, sorbitol, fructose;
phenylketonuria;
active pulmonary tuberculosis;
hypercalcemia (increased calcium levels in the blood – in individuals with increased function of the parathyroid glands);
hypercalciuria (increased excretion of calcium in the urine);
urolithiasis (formation of calcium stones);
sarcoidosis and tumor metastases to bone;
osteoporosis caused by prolonged immobilization;
overdose of vitamin D3
childhood

Side Effects

May experience: constipation, diarrhea, flatulence, nausea, stomach pain. Hypercalcemia and hypercalciuria. Allergic reactions.

Interaction

the activity of vitamin D3 may decrease when used simultaneously with phenytoin or barbiturates;
with simultaneous treatment with cardiac glycosides, monitoring of the ECG and clinical condition of the patient is necessary, because calcium increases the risk of developing cardiac glycoside toxicity;
when using the drug simultaneously with antibiotics from the tetracycline and fluoroquinolone group, the interval between doses should be at least 3 hours, because calcium and vitamin D3 increase the absorption of tetracyclines and fluoroquinolones from the gastrointestinal tract;
the absorption of bisphosphonate or sodium fluoride decreases when used simultaneously with the drug;
corticosteroids reduce calcium absorption;
with the simultaneous use of diuretics from the thiazide group, the risk of hypercalcemia increases due to increased reabsorption of calcium from the lumen of the renal tubules. Furosemide and other “loop” diuretics, on the contrary, increase calcium excretion by the kidneys;
simultaneous treatment with cholestyramine preparations or laxatives based on mineral or vegetable oil may reduce the absorption of vitamin D3;
the acidic reaction of foods increases, and the slightly alkaline reaction of foods reduces calcium absorption.

Overdose

Symptoms: thirst and polyuria, loss of appetite, nausea, vomiting, constipation, dizziness, weakness, headache, fainting, coma; with long-term use: calcification of blood vessels and tissues. Laboratory indicators in case of overdose: hypercalciuria, hypercalcemia (calcium in plasma about 2.6 mmol).
Treatment: rehydration, loop diuretics, glucocorticosteroids, calcitonin, bisphosphonates, calcium-restricted diet, hemodialysis.

Storage conditions

Store at a temperature not exceeding 30 0C.
Keep out of the reach of children.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Italfarmaco S.p.A., Italy