Nais, tablets 100 mg 20 pcs

Pharmacotherapeutic group: nonsteroidal anti-inflammatory drug (NSAID).

CodeATX:M01AX17.

Indications

– rheumatoid arthritis;

– joint syndrome with gout exacerbation;

– psoriatic arthritis;

– ankylosing spondylitis;

– osteochondrosis with radicular syndrome;

– osteoarthritis;

– myalgia of rheumatic and non-rheumatic genesis;

–

Pain syndrome of different genesis (including postoperative period, trauma, algodysmenorrhea, toothache, headache, arthralgia, lumboishalgia).

The drug is intended for symptomatic therapy, reduction of pain and inflammation at the time of use, does not affect the progression of the disease.

Active ingredient

Composition

How to take, the dosage

Interaction

The effect of drugs that reduce blood clotting is increased when they are used simultaneously with nimesulide.

Nimesulide may decrease the effect of furosemide. Nimesulide may increase the possibility of side effects when concomitant use of methotrexate.

Plasma lithium levels are increased when concomitant use of lithium and nimesulide.

Nimesulide may increase the effect of cyclosporine on the kidneys.

The use with glucocorticosteroids, serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Special Instructions

Because Naize® is partially excreted by the kidneys, its dose should be reduced for patients with impaired renal function, depending on creatinine clearance values. Given the reports of visual disturbances in patients taking other NSAIDs, treatment should be stopped immediately if any visual disturbance occurs and the patient should be examined by an ophthalmologist.

The drug may cause fluid retention in tissues; therefore, patients with high blood pressure and with cardiac abnormalities should use Naiz® with extreme caution.

Patients should be monitored regularly if they also take medications with nimesulide that affect the gastrointestinal tract.

In case of signs of liver damage (skin itching, yellowing of the skin, nausea, vomiting, abdominal pain, darkened urine, increased “liver” transaminases) the drug should be stopped and a physician should be consulted. The drug should not be used simultaneously with other NSAIDs.

The drug may modify platelet function, but does not replace the prophylactic effect of acetylsalicylic acid in cardiovascular diseases. The use of the drug may adversely affect female fertility and is not recommended for women planning to become pregnant.

After 2 weeks of using the drug it is necessary to monitor the biochemical parameters of liver function.

This dosage form is contraindicated in children under 12 years of age, but if it is necessary to use nimesulide in children over 7 years of age, dispersible tablets 50 mg and suspension may be used, in strict compliance with the instructions for medical use that are included with them.

As the drug may cause drowsiness, dizziness, and blurred vision, caution should be exercised when driving a vehicle and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Side effects

The frequency of adverse effects is classified according to the frequency of occurrence of the case: frequently (1-10%), sometimes (0.1-1%), rarely (0.01-0.1%), very rarely (less than 0.01%), including individual reports.

Allergic reactions: rare – hypersensitivity reactions; very rare – anaphylactoid reactions.

The central nervous system: infrequent – dizziness; rare – feeling of fear, nervousness, nightmares; very rare – headache, somnolence, encephalopathy (Reis syndrome).

Skin disorders: infrequent itching, rash, increased sweating; rare erythema, dermatitis; very rare: urticaria, angioedema, facial edema, erythema multiforme, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome).

Arenal system: infrequent – edema; rare – dysuria, hematuria, urinary retention, hyperkalemia; very rare – renal failure, oliguria, interstitial nephritis.

Gastro-intestinal tract: frequently – diarrhea, nausea, vomiting; infrequently – constipation, flatulence, gastritis; very rarely – abdominal pain, stomatitis, tar stool, gastrointestinal bleeding, peptic ulcer and/or perforation of the stomach or duodenum.

Hepatic and biliary system disorders: often – increase of “hepatic” transaminases; very rarely – hepatitis, lightning hepatitis, jaundice, cholestasis.

Hematopoietic organs: rarely – anemia, eosinophilia; very rarely – thrombocytopenia, pancytopenia, purpura, prolongation of bleeding time.

Respiratory system: infrequent – shortness of breath; very rare – exacerbation of bronchial asthma, bronchospasm.

Sensory system: infrequent – blurred vision.

Cardiovascular system: infrequent – arterial hypertension; rare – tachycardia, hemorrhages, “hot flashes”. Other: rarely – general weakness; very rarely – hypothermia.

Overdose

Symptoms: apathy, drowsiness, nausea, vomiting. Gastrointestinal bleeding, increased blood pressure, acute renal failure, respiratory depression may occur.

Treatment: symptomatic treatment and supportive care of the patient is required. There is no specific antidote. If overdose occurred within the last 4 hours it is necessary to induce vomiting, provide intake of activated charcoal (60-100 g per adult), osmotic laxatives. Forced diuresis, hemodialysis are ineffective due to high protein binding of the drug.

Similarities