Myofertal 2 g sachets-stick, 30 pcs.

Myo-inositol (inositol, inositol, Vitamin B8) is a water-soluble B vitamin-like compound.

The main function of myo-inositol and its derivatives is to participate in intracellular signal transduction and ensure the functioning of insulin receptors, reproductive hormones, catecholamines, growth factors, etc. Myo-inositol is necessary for functioning of systems and organs of the human body.

. It participates in supporting the cardiovascular system, central nervous system and immunity (decrease of autoimmune inflammatory reactions), in sugar metabolism (mainly in insulin signaling cascade), in regulation of fat metabolism (due to decrease of insulin resistance and increase of production of adiponectin in adipose tissue, the hormone with anti-inflammatory and anti-atherogenic effects).

Myo-inositol improves the transmission of nerve signals. It is effectively included in the complex therapy of diabetic neuropathy and other diseases with impaired nerve sensitivity. Myo-inositol improves concentration and memory ability.

Mio-inositol is most studied as a dietary supplement to improve reproductive function. It is necessary for the reproduction of sperm, and it also has a central role in the triggering mechanism of egg division. Therefore, myo-inositol deficiency can lead to infertility in both sexes.

Lack of myo-inositol supply is associated with menstrual irregularities, infertility, polycystic ovarian disease and congenital fetal malformations. Myo-inositol subsidies improve the formation of ovulatory cycles and mature oocytes, increase the probability of pregnancy, and reduce the risk of gestational diabetes, folate-resistant malformations, and several other fetal malformations. Myo-inositol prevents excessive weight gain during pregnancy, counteracts the formation of glucose tolerance and insulin resistance in women with menstrual irregularities and has a positive effect on the blood lipid profile.

The effects of myo-inositol contributing to the normalization of pathophysiological mechanisms associated with reproductive disorders allow its wide application in obstetrics and gynecology practice and in the combined therapy of infertility. The direct participation of myo-inositol in the restoration of regularity of the menstrual cycle and ovulation determines its successful use in patients with anovulatory cycle.

Myo-inositol is used in the therapy of conditions caused by polycystic ovarian syndrome (PCOS). The development of PCOS and, as a consequence, infertility is based on the insulin sensitivity disorder of the body’s tissues and ovaries, which can be normalized by myo-inositol. Taking myo-inositol not only helps to restore the ovarian-menstrual cycle, but also reduces symptoms of hirsutism, improves the hair, normalizes blood pressure and reduces body weight. Against the background of taking myo-inositol women’s self-esteem increases.

The results of the analysis of multicenter randomized trials allow recommending myo-inositol at a dose of 2-4 g/day to improve ovarian function as well as metabolic and hormonal parameters in patients with PCOS.

Folic acid is a water-soluble B vitamin (vitamin B9) and refers to folate: a group of related compounds with folic acid activity. Folic acid has much greater bioavailability than natural folate and is quickly absorbed in the small intestine. Folic acid plays an important role in amino acid metabolism, protein and nucleic acid synthesis (primarily in DNA and RNA production) and chromosome repair, so it is very important for normal cell division and tissue growth.

Numerous studies have convincingly demonstrated the exceptional role of folic acid in the functioning of the reproductive system. Most researchers have concluded that folic acid deficiency in the serum leads to impaired follicular development and oocyte immaturity, to a disturbance of the ovarian reserve and prevents pregnancy in patients.

The intake of folic acid is extremely important because it prevents the occurrence of congenital malformations, including defects in the formation of the neural tube (the future nervous system of the child). To prevent neural tube defects and other malformations and complications of pregnancy, all women, without exception, preparing for conception should take folate at a dose of 400-800 mcg per day for 3 months before conception and at least during the first trimester of pregnancy. Nonprescription of folic acid, as prescribed in medical orders and clinical guidelines, is counted as a defect in the provision of medical care.

Myo-inositol and folic acid are natural synergists. Myo-inositol, like folate, affects DNA methylation processes through inositol-dependent proteins. The combination of myo-inositol and folic acid has proven effective in numerous studies and is used to normalize the menstrual cycle, restore ovulation and eliminate skin problems (acne, seborrhea and hirsutism). The combination of myo-inositol and folic acid has shown a significant improvement in ovarian function in women with PCOS compared to folic acid intake alone.

Indications

As an additional source of myo-inositol and folic acid for patients of both sexes.

As an adjuvant (dietary supplement) in the treatment of conditions caused by polycystic ovary syndrome (PCOS):

· to restore ovarian function and the menstrual cycle;

· to reduce testosterone synthesis in women and eliminate the clinical manifestations of androgenic disorders (hirsutism, oily skin, acne, greasiness and hair loss);

· for the onset of a desired pregnancy;

· to improve the quality of mature oocytes in preparation for in vitro fertilization;

· in combination therapy of conditions caused by insulin resistance, incl. androgenic obesity (together with nutrition correction and physical activity).

For the prevention of neural tube defect, other fetal malformations and complicated pregnancy during 3 months before pregnancy and the first trimester of pregnancy.

Pharmacological effect

Myo-inositol (inositol, inositol, Vitamin B8) is a water-soluble vitamin-like compound of group B.

The main function of myo-inositol and its derivatives is to participate in intracellular signal transmission and ensure the functioning of insulin receptors, reproductive hormones, catecholamines, growth factors, etc. Myo-inositol is necessary for the functioning of systems and organs of the human body.

It is involved in supporting the functioning of the cardiovascular system, central nervous system, immunity (reducing autoimmune inflammatory reactions), in the metabolism of sugars (primarily in the insulin signaling cascade), in the regulation of fat metabolism (by reducing insulin resistance and increasing the production of adiponectin in adipose tissue, a hormone that has anti-inflammatory and antiatherogenic effects).

Myo-inositol improves the transmission of nerve signals. It is effectively included in the complex therapy of diabetic neuropathy, as well as other diseases with impaired nerve sensitivity. Myo-inositol helps improve concentration and memory.

Myo-inositol is the most studied as a dietary supplement that improves reproductive function. It is necessary for the reproduction of sperm, and it plays a central role in the triggering mechanism of egg division. Therefore, myo-inositol deficiency can lead to infertility in both sexes.

Insufficient supply of myo-inositol is associated with menstrual irregularities, infertility, polycystic ovary syndrome and congenital fetal defects. Myo-inositol subsidies improve the formation of ovulatory cycles, mature oocytes, increase the likelihood of pregnancy, reduce the risk of gestational diabetes, folate-resistant malformations and some other fetal defects. Myo-inositol prevents excess weight gain during pregnancy, counteracts the formation of glucose tolerance and insulin resistance in women with menstrual irregularities, and has a beneficial effect on the blood lipid profile.

The effects of myo-inositol, which contribute to the normalization of pathophysiological mechanisms associated with reproductive disorders, enable its widespread use in obstetric and gynecological practice and in combination therapy for infertility. The direct participation of myo-inositol in restoring the regularity of the menstrual cycle and ovulation determines its successful use in patients with an anovulatory cycle.

Myo-inositol is used in the treatment of conditions caused by polycystic ovary syndrome (PCOS). The development of PCOS and, as a consequence, infertility is based on a violation of the sensitivity of body tissues and ovaries to insulin, which myo-inositol can help normalize. Taking myo-inositol not only helps restore the ovarian-menstrual cycle, it also helps reduce the manifestations of hirsutism, improve hair condition, normalize blood pressure, and reduce body weight. While taking myo-inositol, a woman’s self-esteem increases.

Due to the irregularity of the menstrual cycle and anovulation, many women with PCOS cannot conceive on their own and constitute the main group of women who resort to in vitro fertilization (IVF). Myo-inositol is used to increase pregnancy rates in infertile women undergoing ovulation induction or in vitro embryo transfer.

The results of an analysis of multicenter randomized studies allow us to recommend myo-inositol at a dose of 2-4 g/day to improve ovarian function, as well as metabolic and hormonal parameters in patients with PCOS.

Folic acid is a water-soluble B vitamin (vitamin B9) and belongs to the folates: a group of related compounds that have the activity of folic acid. Folic acid has much greater bioavailability than natural folates and is rapidly absorbed in the small intestine. Folic acid plays an important role in amino acid metabolism, protein and nucleic acid synthesis (primarily DNA and RNA production) and chromosome repair, so it is very important for normal cell division and tissue growth.

Numerous studies have convincingly proven the exceptional role of folic acid in the functioning of the reproductive system. Most researchers have come to the conclusion that a deficiency of folic acid in the blood serum leads to impaired follicle development and immaturity of the egg, impaired ovarian reserve and prevents pregnancy in patients.

Taking folic acid is extremely important, as it prevents the occurrence of congenital malformations, incl. defects in the formation of the neural tube (the future nervous system of the child). To prevent defects in the formation of the neural tube, other malformations and complicated pregnancy, all women without exception who are preparing to conceive need to take folates in a dosage of 400–800 mcg/day for 3 months before conception and at least during the first trimester of pregnancy. Failure to prescribe folic acid as prescribed by medical care procedures and clinical guidelines is considered a defect in the provision of medical care.

Myo-inositol and folic acid are natural synergists. Myo-inositol, like folates, affects DNA methylation processes through inositol-dependent proteins. The combination of myo-inositol and folic acid has proven its effectiveness in numerous studies and is used to normalize the menstrual cycle, restore ovulation and eliminate skin problems (acne, seborrhea and hirsutism). The combination of myo-inositol and folic acid showed a significant improvement in ovarian function in women with PCOS compared to folic acid alone.

Composition

Content of active ingredients in 1 stick sachet:

Myo-inositol – 1000 mg. (Myo-inositol – 1000 mg)

Folic acid – 200 mcg. (Acidum folicum – 200 mcg)

The content of myo-inositol and folic acid in the Myofertal stick bag does not exceed the upper permissible level of consumption allowed by Russian legislation [1]

1. Uniform sanitary-epidemiological and hygienic requirements for products (goods) subject to sanitary-epidemiological supervision and control (as amended as of May 21, 2019), Chapter 2, Appendix 5.

Contraindications

Individual intolerance to components.

Short product description

Dietary supplement Not a medicine.
Before use, it is recommended to consult a doctor (specialist).

Recommendations for use

As an additional source of myo-inositol and folic acid, it is recommended to take 1 stick per day at any time of the day during or after meals. Duration of admission: 30 days.

On the recommendation of a doctor, the frequency and duration of administration can be changed. In the treatment of conditions accompanied by an increased need for myo-inositol and folic acid, the daily dose usually does not exceed 2-4 g of myo-inositol and 400-800 mcg of folic acid, which corresponds to the contents of 2-4 stick sachets.

Duration of treatment is 3-6 months.

Storage conditions

Store in a place protected from direct sunlight and out of reach of children at a temperature not exceeding 25°C.

Shelf life

24 months. The product should be used within the expiration date indicated on the packaging

Manufacturer

SOKIM International S.p.A., Italy