Milk thistle meal, 100 g

Milk thistle interacts with free radicals in the liver and reduces their toxicity. By interrupting the process of lipid peroxidation, it prevents further destruction of cell structures.

In damaged hepatocytes it stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA-polymerase A), stabilizes cell membranes, prevents the loss of cellular components and intracellular enzymes (transaminases) and accelerates the regeneration of liver cells.

Inhibits penetration into cells of some hepatotoxic substances (poisons of the pale grebes fungus). It is subjected to enterohepatic circulation. It is metabolized in the liver by conjugation. It is excreted mainly with bile in the form of glucuronides and sulfates, to a small extent with urine.

It does not cumulate. After repeated oral administration of 140 mg 3 times a day a stable concentration is reached.

It improves the general state of patients with liver diseases, decreases subjective complaints, normalizes laboratory indexes (activity of transaminases, gamma-glutamyltransferase, alkaline phosphate, bilirubin level).

Long-term use significantly increases survival rate of patients with liver cirrhosis.

Indications

Improvement of liver function

• toxic liver damage (alcoholism, intoxication with halogenated hydrocarbons, heavy metals compounds, drug-induced liver damage) and its prevention;
• chronic hepatitis;

cirrhosis of the liver (as part of complex therapy;

• conditions after infectious and toxic hepatitis;

hyperthesis and fatigue.Chronic hepatitis;

• Hepatic cirrhosis (as a part of complex therapy);
• state after infectious and toxic hepatitis; liver dystrophy and fatty infiltration;
• correction of lipid metabolism disorders.

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Composition

Milk thistle extract (silymarin) + excipients

How to take, the dosage

Take adults and children over 12 years old 1 teaspoon of powder (3.5 g) a day with meals, drinking plenty of fluids.

Duration of use – 1 month.

Interaction

When using milk thistle together with oral hormonal contraceptives and drugs intended for hormone replacement therapy, it is possible to reduce the effects of the latter.

Silimarin may increase the effects of diazepam, alprazolam, ketoconazole, lovastatin, vinblastine due to its inhibitory action on microsomal enzymes of cytochrome P450 system.

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Contraindications

Hypersensitivity

Side effects

• diarrhea;
• allergic reactions;
• children under 12 years of age;
• high sensitivity to the components of the drug.

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