Midocalm, 50 mg 30 pcs.

Midocalm is a myorelaxant.

Pharmacodynamics

Myorelaxant of central action. The mechanism of action is not fully elucidated. It has membrane stabilizing, local anesthetic action, inhibits conduction of impulses in primary afferent fibers and motor neurons which leads to blocking of spinal mono- and polysynaptic reflexes. < br>

It also probably secondary inhibits mediator release by inhibiting Ca2+ entry into synapses. In the brainstem, it eliminates the facilitation of excitation conduction along the reticulospinal pathway. It enhances the peripheral blood flow independently of the CNS influence. The weak antispasmodic and adrenoblocking effect of tolperizone plays a role in the development of this effect.

Pharmacokinetics

Tolperisone is well absorbed from the gastrointestinal tract after oral administration. Cmax is reached after 0.5-1 h, bioavailability is about 20%.

Tolperisone is metabolized in the liver and kidneys. It is excreted in the urine as metabolites (more than 99%). The pharmacological activity of the metabolites is unknown.

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Indications

Active ingredient

Composition

Active ingredient:

tolperisone hydrochloride;

Associates:

citric acid monohydrate;

colloidal silicon dioxide;

stearic acid;

talc;

MCC;

corn starch;

lactose monohydrate;

film jacket:

colloidal silicon dioxide;

titanium dioxide (E171 – 77891);

p> lactose monohydrate;

MacroGol 6000;

Hypromellose

How to take, the dosage

In most cases, adults are prescribed 150 mg 3 times a day.

In children aged 1-6 years, Midocalm is prescribed orally in a daily dose of 5-10 mg/kg (in 3 doses during the day); aged 7-14 years, in a daily dose of 2-4 mg/kg in 3 doses.

Interaction

There are no data on interactions limiting the use of the drug Midocalm.

While tolperizone has an effect on the CNS, it does not cause sedation, so it can be used in combination with sedatives, hypnotics and drugs containing alcohol.

It does not affect the effect of alcohol on the CNS.

Tolperisone enhances the effect of niflumic acid, with the simultaneous use of these drugs may require reducing the dose of niflumic acid.

The means for general anesthesia, peripheral myorelaxants, psychotropic drugs, clonidine – increase the effect of tolperizone.

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Special Instructions

Use strictly on prescription to avoid complications.

Impact on driving and operating ability.

There have been no studies, but in the many years of using the drug there has been no such information.

Contraindications

Side effects

Overdose

There have been no reports of overdose with Midocalm.

Pregnancy use

The drug Midocalm is contraindicated in pregnancy, lactation and children under 3 years of age.

Similarities