Mezim forte, 20 pcs.

Pharmacotherapeutic group: digestive enzyme agent

ATX code: A09AA02

Pharmacological properties

Pancreatin is a powder from the pancreas of pigs.

Pancreatic enzymes (lipase, amylase, protease) have proteolytic, amylolytic and lipolytic effects and contribute to the breakdown of proteins, fats, carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing the digestive processes. It is assumed to inhibit active trypsin by feedback type of stimulated pancreatic secretion in the upper part of the small intestine. Analgesic effect of pancreatin preparations described in some cases is attributed to this effect. Pancreatic enzymes are not absorbed in the gastrointestinal tract and are excreted through the intestine, most of them being denatured by digestive juices.

Indications

Active ingredient

Composition

1 coated tablet contains:

Kernel:

Active substance:
Pancreatin* – 116.66 – 134.61 mg with minimal activity:

Auxiliary substances:Microcrystalline cellulose (type 12), sodium carboxy-methyl starch (type A), colloidal anhydrous silica, magnesium stearate.

Wrapper: talc, hypromellose, azorubin dye (E 122), simethicone emulsion 30% (dry mass), polyacrylate dispersion 30% (dry mass), titanium dioxide (E 171), macrogol 6000.
*derived from the pancreatic glands of pigs

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How to take, the dosage

The dose of the drug Mesim® forte is determined individually depending on the degree of digestive disorders.

Adults: 1 to 2 tablets before meals orally, without chewing and with water (the effectiveness of Mesim® forte may decrease if chewed, and pancreatic enzymes may irritate the oral mucosa when released).

If necessary, take 2 to 4 more tablets with meals.

If higher doses of pancreatin are required, the physician should be consulted to prescribe a higher dose depending on the symptoms (e.g., reduction in severity of steatorrhea, abdominal pain).

The duration of treatment may vary from a few days (for digestive problems caused by poor diet) to several months or even years (if permanent replacement therapy is necessary).

In children the drug is used by prescription.

Interaction

Special Instructions

The drug Mesim® forte contains active enzymes which, if released in the oral cavity, e.g. when chewed, may damage the oral mucosa (up to and including ulceration). This is why the tablet must be swallowed whole.

Influence on the ability to drive vehicles and other mechanisms

The drug Mesim® forte has no effect or a slight effect on the ability to drive vehicles and mechanisms.

Synopsis

Contraindications

Side effects

Possible side effects are listed below in descending frequency of occurrence: very frequently (≥ 1/10), frequently (≥ 1/100, < 1/10), infrequently (≥ 1/1000, < 1/100), rarely (≥ 1/10000, < 1/1000), very rarely (< 1/10000), frequency unknown (no data available to estimate).

Immune system disorders
Very rare:allergic reactions of immediate type.
Frequency unknown:possible allergic reactions to components of the drug (see “Composition” section).

Gastrointestinal disorders
Very rare: gastrointestinal tract hypersensitivity (e.g., diarrhea, epigastric discomfort, nausea).

Overdose

Pregnancy use

Similarities