Metrogil Plus, vaginal gel 50 g 1 pc + applicators 10 pcs
€12.48 €10.92
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Combination drug for intravaginal use, the effectiveness of which is due to the presence in its composition of two components: metronidazole and clotrimazole. Metronidazole is active against protozoa: Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis as well as Gram-negative anaerobes: Bacteroides fragilis, Fusobacterium spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens), Gardnerella vaginalis and some Gram-positive microorganisms: Clostridium perffringens, Clostridium difficile, Peptococcus spp., Peptostreptococcus spp. The MPC for these strains is 0.125-6.25 µg/ml.
Clotrimazole has fungicidal and bactericidal action. Inhibits the biosynthesis of ergosterol, which regulates the permeability of the cell wall of microorganisms. In low concentrations it is fungistatic and in high concentrations it is fungicidal.
Indications
Trichomoniasis, Vaginitis, Inflammation, Genital itching and dryness, Female genital inflammationBacterial vaginosis of various etiologies confirmed by clinical and microbiological data; Candida vulvovaginitis and vulvovaginitis, urogenital trichomoniasis.
Composition
1 gram of the gel contains:
The active ingredients:
Metronidazole 10 mg
Clotrimazole 20 mg
Excipients: methylhydroxybenzoate, propylhydroxybenzoate, diatrium edetate, propylene glycol, carbomer-940, benzyl alcohol, sodium hydroxide, purified water.
How to take, the dosage
The drug is administered intravaginally. The recommended dose is 5 g (one full applicator) 2 times a day (morning and evening). The course of treatment is 5 days. If necessary, the course of treatment may be repeated after 2 weeks.
Interaction
When used simultaneously Metrogil Plus increases the effect of indirect anticoagulants.
Combined use with non-depolarizing myorelaxants (vecuronium) is not recommended.
Concomitant use with lithium preparations may increase concentration of lithium in blood plasma.
Phenobarbital accelerates metabolism of metronidazole due to induction of microsomal liver enzymes, cimetidine decreases it.
Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole in concomitant use.
In concomitant use with ethanol the drug may cause disulfiram-like reactions.
Special Instructions
When using the drug the use of alcohol is contraindicated (development of disulfiram-like reaction is possible: spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).
Metronidazole may immobilize treponemes and lead to a false positive Nelson test.
The drug is intended for intravaginal use only.
Avoid contact of the drug in the eyes.
During the course of therapy it is necessary to refrain from sexual activity.
Contraindications
Leukopenia (including anamnesis); organic CNS lesion (including epilepsy); hepatic insufficiency; I trimester of pregnancy; hypersensitivity to components of the drug Metrogil Plus.
Side effects
Local reactions: burning sensation or frequent urination; in the sexual partner – a burning sensation or irritation of the penis.
Possible development of systemic effects: dizziness, headache, nausea, spastic abdominal pain.
Allergic reactions: skin rash, urticaria. In case of any undesirable side effects it is necessary to stop treatment and consult a physician!
Overdose
No cases of overdose of the drug were observed when prescribed in the recommended doses.
Weight | 0.170 kg |
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Manufacturer | Unique Pharmaceutical Laboratories, India |
Medication form | vaginal gel |
Brand | Unique Pharmaceutical Laboratories |
Other forms…
Gynecology and Obstetrics
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