Metrogil, gel 30 g

An antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. Mechanism of action consists in biochemical reduction of 5-nitrogroup of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitrogroup of metronidazole interacts with the DNA of the microbial cell, inhibiting the synthesis of their nucleic acids, which leads to the death of the bacteria.

Active against Trichomonas vaginalis, as well as Gram-negative anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some Gram-positive microorganisms (sensitive strains of Eubacterium spp, Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). MPC for these strains is 0.125-6.25 µg/ml.

When applied topically it has an anti-acne action which mechanism is not known exactly (it is not connected to the action on the mite Demodex folliculorum which is found in hair follicles and sebaceous glands secretion and it does not have any influence on production of this secretion).

Metronidazole for external use may have antioxidant activity. It has been found to significantly reduce the production by neutrophils of reactive oxygen, hydroxyl radicals and hydrogen peroxide, which are potential oxidants that can cause tissue damage at the site of inflammation. Metronidazole for external use is ineffective against telangiectasias seen in pink acne.

Metronidazole is insensitive to aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes.

Indications

Bedsores, Trophic ulcers, Hemorrhoids, Common acne (vulgar), Dermatitis, Seborrheic dermatitis, Anal fissures, WoundsPink acne (incl. Pink acne (including post-steroidal), vulgar acne, infectious skin diseases, trophic ulcers of lower extremities (against the background of varicose veins, diabetes), sluggish wounds, bedsores, burns, eczema, seborrheic eczema, greasy seborrhea, seborrheic dermatitis, hemorrhoids, anal fissures.

Active ingredient

Metronidazole

Composition

Composition per 1 g gel:

The active ingredient:

metronidazole – 10.0 mg;