Metrogil, gel 30 g

An antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. Mechanism of action consists in biochemical reduction of 5-nitrogroup of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitrogroup of metronidazole interacts with the DNA of the microbial cell, inhibiting the synthesis of their nucleic acids, which leads to the death of the bacteria.

Active against Trichomonas vaginalis, as well as Gram-negative anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some Gram-positive microorganisms (sensitive strains of Eubacterium spp, Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). MPC for these strains is 0.125-6.25 µg/ml.

When applied topically it has an anti-acne action which mechanism is not known exactly (it is not connected to the action on the mite Demodex folliculorum which is found in hair follicles and sebaceous glands secretion and it does not have any influence on production of this secretion).

Metronidazole for external use may have antioxidant activity. It has been found to significantly reduce the production by neutrophils of reactive oxygen, hydroxyl radicals and hydrogen peroxide, which are potential oxidants that can cause tissue damage at the site of inflammation. Metronidazole for external use is ineffective against telangiectasias seen in pink acne.

Metronidazole is insensitive to aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against common aerobes.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

It is not recommended to prescribe the drug to pregnant women in the first trimester of pregnancy.

In the period of lactation, if it is necessary to prescribe the drug, the question of stopping breastfeeding should be solved.

Information about the possible effect of the drug for medical use on the ability to drive vehicles, machinery.

The drug does not affect the ability to drive vehicles and operate moving mechanical equipment.

Contraindications

Side effects

Overdose

There have been no cases of overdose of the drug when administered in the recommended doses.

Similarities