Metoclopramide, tablets 10 mg 56 pcs

Pharmacodynamics

Antiemetic, is a specific blocker of dopamine (D2) and serotonin receptors. It has antiemetic effect, eliminates nausea and hiccups. It reduces esophageal motility, increases the tone of the lower esophageal sphincter, accelerates gastric emptying, and also accelerates the movement of food through the small intestine without causing diarrhea. Normalizes the secretion of bile, reduces spasm of the sphincter of Oddi, eliminates gall bladder dyskinesia. It stimulates the secretion of prolactin.

Pharmacokinetics

Fast absorption from the gastrointestinal tract. Bioavailability is 60-80%. Time of maximum concentration achievement in blood plasma is 1-2 hours. The elimination half-life is 3 to 5 hours, with impaired renal function up to 14 hours. The drug is eliminated mainly by the kidneys within 24 hours in unchanged form and as conjugates. Passes through the placental and blood-brain barrier, passes into the mother’s milk.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

When concomitant use of Metoclopramide with some drugs the following effects may occur: Ethanol: increased effect on the central nervous system; Cholinesterase inhibitors: weakening of metoclopramide action; Sleeping pills: increased sedative effect; H2-histamine receptor blockers: increased effectiveness of therapy; Diazepam, tetracycline, ampicillin, paracetamol, acetylsalicylic acid, levodopa, ethanol: increased absorption; Digoxin, cimetidine: delayed absorption; Neuroleptics: increased risk of extrapyramidal symptoms.

Consult a physician before concomitant use of Metoclopramide with other medicinal agents.

Special Instructions

Contraindications

Side effects

Cardiovascular system: atrioventricular block;

Central nervous system: Extrapyramidal disorders – trismus, facial muscle spasm, spastic torticollis, bulbar speech type, rhythmic tongue protrusion, extraocular muscle spasm (including oculogyric crisis), muscle opisthotonus, hypertonus; parkinsonism (muscle rigidity, hyperkinesis – manifestation of dopamine-blocking action, the risk of development in children increases when the dose of 0.5 mg/kg per day is exceeded), dyskinesia (in chronic renal failure and elderly patients), depression, headache, drowsiness, anxiety, fatigue, confusion, tinnitus;

Endocrine system: rarely (with prolonged therapy in high doses) – galactorrhea, gynecomastia, menstrual disorders;

Digestive system: diarrhea, constipation; rarely – dry mouth;

Hematopoietic system: Leukopenia, neutropenia, sulfhemoglobinemia in adults;

Metabolism: porphyria;

Allergic reactions: Angioneurotic edema, bronchospasm, urticaria;

Other: at the beginning of treatment – agranulocytosis; rarely (when using high doses) – nasal mucosal hyperemia.

In case of the above symptoms, their worsening or other side effects should be seen by a physician.

Overdose

Pregnancy use

Similarities