Metoclopramide, tablets 10 mg 50 pcs
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Metoclopramide is an antiemetic; it helps to reduce nausea, hiccups; it stimulates gastrointestinal peristalsis. Antiemetic effect is caused by blockade of dopamine D2-receptors and increase of threshold of trigger zone chemoreceptors; it is a blocker of serotonin receptors.
It is believed that metoclopramide inhibits dopamine-induced relaxation of gastric smooth muscle, thus increasing cholinergic responses of gastrointestinal smooth muscle. Helps accelerate gastric emptying by preventing relaxation of the gastric body and increasing activity of the antral stomach and upper small intestine.
It reduces reflux of contents into the esophagus by increasing esophageal sphincter pressure at rest and increases clearance of acid from the esophagus by increasing the amplitude of its peristaltic contractions.
Methoclopramide stimulates prolactin secretion and causes a transient increase in circulating aldosterone levels, which may be accompanied by transient fluid retention.
Indications
Biliary dyskinesia, Gastric and duodenal ulcers, Reflux esophagitis, Nausea, Vomiting, Meteorism, Hiccups
- Vomiting, nausea, hiccups of various genesis (in some cases it may be effective for vomiting caused by radiation therapy or taking cytostatics);
- atony and hypotonia of the stomach and intestines (particularly postoperative);
- dyskinesia of the biliary tract by hypomotor type;
- reflux esophagitis;
- meteorism;
- functional gateway stenosis; .
- in the complex therapy of exacerbations of gastric ulcer and duodenal ulcer;
- used to enhance peristalsis during GI x-ray studies;
- as a tool to facilitate duodenal probing (to speed up gastric emptying and food movement through the small intestine).
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Active ingredient
Metoclopramide
Composition
1 tablet contains:
The active ingredient:
metoclopramide hydrochloride 10 mg;
Excipients:
lactose;
corn starch;
talc purified;
p> magnesium stearate;
sodium starch glycolate;
anhydrous colloidal silica.
How to take, the dosage
The tablets are taken 30 minutes before a meal with a small amount of water.
Adults – 5-10 mg 3-4 times a day.
The maximum single dose is 20 mg, the daily dose is 60 mg.
Children over 6 years of age – 5 mg 1-3 times a day.
Interaction
The effects of concomitant use with anticholinergic agents may be mutually attenuated.
Concomitant use with neuroleptics (especially phenothiazine series and butyrophenone derivatives) increases the risk of extrapyramidal reactions.
Concomitant use increases absorption of acetylsalicylic acid, paracetamol, ethanol.
Methoclopramide when administered by IV increases the rate of absorption of diazepam and increases its maximum plasma concentration.
Concomitant use with the slow-dissolving form of digoxin may decrease the serum concentration of digoxin by 1/3. When concomitant use with digoxin in liquid dosage form or as a rapidly soluble dosage form, no interaction has been noted.
In concomitant use with zopiclone absorption of zopiclone is accelerated; with cabergoline – possible decrease of cabergoline effectiveness; with ketoprofen – bioavailability of ketoprofen is decreased.
Because of antagonism to dopamine receptors, metoclopramide can decrease antiparkinsonian effect of levodopa, and bioavailability of levodopa may increase due to accelerated evacuation from the stomach under the influence of metoclopramide. The results of the interaction are equivocal.
Concomitant use with mexiletine results in faster absorption of mexiletine; with mefloquine – increased absorption rate of mefloquine and its concentration in plasma, while possible reduction of its side effects.
Concomitant use with morphine accelerates absorption of morphine when ingested and increases its sedative effect.
Concomitant use with nitrofurantoin decreases absorption of nitrofurantoin.
If metoclopramide is used immediately prior to the administration of propofol or thiopental, it may be necessary to reduce their induction doses.
In patients receiving metoclopramide, the effects of suxamethonium chloride are enhanced and prolonged.
Concomitant use with tolterodine decreases the effectiveness of metoclopramide; with fluvoxamine, there is a described case of extrapyramidal disorders; with fluoxetine, there is a risk of extrapyramidal disorders; with cyclosporine, the absorption of cyclosporine increases and its concentration in blood plasma increases.
Special Instructions
With caution use in patients with bronchial asthma, arterial hypertension, hepatic and/or renal dysfunction, Parkinson’s disease.
Particular caution should be used in children, especially young children, because they have a significantly higher risk of dyskinetic syndrome. Metoclopramide may in some cases be effective in vomiting caused by taking cytostatics.
When used in elderly patients, it should be borne in mind that extrapyramidal disorders, especially parkinsonism and tardive dyskinesia, are the most common side effect with long-term use of metoclopramide at high or medium doses.
In the background of metoclopramide use, distortions of laboratory data of liver function and determination of plasma concentrations of aldosterone and prolactin are possible.
Impact on the ability to drive and operate machinery
Potentially dangerous activities requiring increased attention and quick psychomotor reactions should be avoided during treatment.
Contraindications
- bleeding from the gastrointestinal tract;
- gastric pylorus stenosis;
- intestinal obstructionmechanical bowel obstruction;
- perforation of the stomach or intestinal wall;
- pheochromocytoma;
- epilepsy;
- glaucoma;
- extrapyramidal disorders;
- Parkinson’s disease;
- prolactin-dependent tumors;
- vomiting as a result of treatment or overdose of neuroleptics and in patients with breast cancer;
- bronchial asthma in patients with hypersensitivity to sulfites;
- pregnancy (first trimester), lactation period;
- Early childhood (children under 2 years of age – contraindicated for the use of metoclopramide in any dosage form, children under 6 years – contraindicated for parenteral administration);
- hypersensitivity to metoclopramide or any of the drug components.
Do not prescribe after gastrointestinal surgery (such as pyloroplasty or bowel anastomosis) because vigorous muscle contractions impede healing.
If you are hypersensitive to metoclopramide or other components of the drug, be sure to consult your physician before taking it.
With caution: bronchial asthma, arterial hypertension, Parkinson’s disease, renal and/or hepatic impairment, older age (over 65), childhood (increased risk of dyskinetic syndrome).
Side effects
Digestive system disorders: at the beginning of treatment constipation, diarrhea are possible; rarely – dry mouth.
CNS disorders: at the beginning of treatment fatigue, drowsiness, dizziness, headache, depression, akathisia are possible. Extrapyramidal symptoms may occur in children and young patients (even after single use of metoclopramide): facial spasm, hyperkinesias, spastic torticollis (they usually disappear immediately after discontinuation of metoclopramide). With long-term use, more often in elderly patients, phenomena of parkinsonism and dyskinesia are possible.
The hematopoietic system: at the beginning of treatment agranulocytosis is possible.
Endocrine system disorders: rarely, with prolonged use in high doses – galactorrhea, gynecomastia, menstrual disorders.
Allergic reactions: rare – skin rash.
Pregnancy use
It is contraindicated for use in pregnancy.
When using during lactation (breast-feeding) it should be taken into account that metoclopramide penetrates into the breast milk.
In experimental studies no adverse effects of metoclopramide on the fetus have been established.
Similarities
Cerucal, Metoclopramide
Weight | 0.030 kg |
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Shelf life | 2 years |
Conditions of storage | In a dry, light-protected place |
Manufacturer | Moscow Endocrine Plant, Russia |
Medication form | pills |
Brand | Moscow Endocrine Plant |
Other forms…
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