Memaneirin, drops 10 mg/ml 50 ml

Memantine is a drug that improves brain metabolism and is used for the treatment of dementia; it has a myorelaxant effect. It has nootropic, cerebrovasodilator, antihypoxic, neuroprotective and psychostimulant effects.

As a non-competitive antagonist of N-methyl-D-aspartate (NMDA)-receptors it has modulating effect on glutamatergic system.

It regulates ion transport; blocks calcium channels,normalizes membrane potential, improves nerve impulse transmission, improves cognitive processes, memory and learning ability, increases daily activity.

Indications

– Alzheimer’s type dementia;

– vascular dementia;

– mixed dementia of all degrees of severity.

Pharmacological effect

Memantine is a drug that improves brain metabolism and is used to treat dementia; has a muscle relaxant effect. It has nootropic, cerebrovasodilating, antihypoxic, neuroprotective and psychostimulating effects.

As a non-competitive antagonist, N-methyl-D-aspartate (NMDA) receptors have a modulating effect on the glutamatergic system.

Regulates ion transport; blocks calcium channels, normalizes membrane potential, improves the process of nerve impulse transmission, improves cognitive processes, memory and learning ability, increases daily activity.

Special instructions

For elderly patients, it is preferable to prescribe the drug in the form of drops.

The optimal dose is achieved gradually, with the dose increasing every week.

For patients with impaired renal function, the dosage regimen is set individually, depending on clinical effectiveness, under the control of renal function during treatment.

Use with caution while working for vehicle drivers and people whose profession involves increased concentration of attention.

Active ingredient

Memantine

Composition

1 ml – memantine hydrochloride 10 mg.

Excipients:

potassium sorbate – 2.0 mg,

sorbitol – 70.0 mg,

purified water – up to 1 ml.

Pregnancy

Memaneurin is contraindicated for use during pregnancy.

Contraindications

– severe impairment of kidney and liver function;

– pregnancy;

– breastfeeding;

– children under 18 years of age (due to insufficient data);

– hypersensitivity to the drug.

With caution: the drug is prescribed for thyrotoxicosis, epilepsy, seizures (including history), myocardial infarction, heart failure.

Side Effects

Adverse reactions are classified according to clinical manifestations (according to the damage to certain organ systems) and frequency of occurrence: very often (≥ 1/10), often (≥1/100 to < 1/10), not often (≥ 1/1,000 to ≤ 1/100), rarely ≥1/10,000 to ≤ 1/1,000, very rare (≤ 1/10,000).

From the body as a whole – common adverse reactions
Often
Headache
Rarely
Fatigue
Infections
Rarely
Fungal infections
Mental disorders
Often
Drowsiness
Rarely
Confusion
Rarely
Hallucinations1
Cardiovascular disorders
Rarely
Hypertension
Rarely
Venous thrombosis/thromboembolism
Gastrointestinal disorders
Often
Constipation
Rarely
Nausea, vomiting
Disorders of the central and peripheral nervous system
Often
Dizziness
Rarely
Gait disturbance
Very rarely
Convulsions

1Hallucinations have been observed mainly in patients with Alzheimer’s disease at the stage of severe dementia.

Interaction

When used simultaneously with levodopa, dopamine agonists, and anticholinergics, the effect of the latter may be enhanced.

Overdose

Symptoms: the manifestations of the described side effects may increase.

Treatment: gastric lavage, taking activated carbon; If necessary, carry out symptomatic therapy.

Storage conditions

In a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

ZAO BIS, Russia