Meldonium, 250 mg capsules 30 pcs

Meldonium is an analogue of gamma-butyrobetaine, inhibits gamma-butyrobe-tainhydroxinase, reduces carnitine synthesis and transport of long-chain fatty acids through cell membranes, prevents the accumulation of activated forms of unoxidized fatty acids in cells – derivatives of acylcarnitine and acylkoenzyme A. As a result of reducing the concentration of carnitine gamma-butyrobetaine, which has vasodilatory properties, is synthesized intensively.

In ischemia conditions it restores equilibrium of oxygen delivery and consumption in cells, prevents the violation of ATP transport, and simultaneously activates glycolysis, which proceeds without additional oxygen consumption.

The mechanism of action determines the diversity of its pharmacological effects: increase efficiency, reduction of symptoms of mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect. In acute ischemic myocardial injury slows the formation of necrotic zone, shortens the rehabilitation period.

In heart failure increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebral circulatory disorders it improves blood circulation in ischemic area and redistributes the blood in favor of ischemic area.

Effective in cases of vascular and dystrophic eye fundus pathology. Also it is characterized by tonic effect on the central nervous system, elimination of functional disorders of somatic and vegetative nervous systems in patients with alcoholism during withdrawal.

Indications

As part of combination therapy for coronary heart disease, chronic heart failure, cardialgia against the background of dishormonal myocardial dystrophy.

Disorders of the blood supply to the brain (stroke, cerebrovascular insufficiency). Complex therapy of alcohol withdrawal syndrome.

Reduced performance, chronic physical overstrain, postoperative period to accelerate rehabilitation processes.

Pharmacological effect

Meldonium is an analogue of gamma-butyrobetaine, suppresses gamma-butyrobetaine hydroxinase, reduces the synthesis of carnitine and the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids – derivatives of acylcarnitine and acyl coenzyme A. As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine is intensively synthesized, which has vasodilating properties.

Under conditions of ischemia, it restores the balance of the processes of oxygen delivery and its consumption in cells, prevents disruption of ATP transport; At the same time, it activates glycolysis, which occurs without additional oxygen consumption.

The mechanism of action determines the variety of its pharmacological effects: increased performance, reduced symptoms of mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect. In case of acute ischemic damage to the myocardium, it slows down the formation of the necrotic zone and shortens the rehabilitation period.

In heart failure, it increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks. In acute and chronic ischemic disorders of cerebral circulation, it improves blood circulation in the ischemic area, promotes the redistribution of blood in favor of the ischemic area.

Effective in cases of vascular and dystrophic pathology of the fundus. It is also characterized by a tonic effect on the central nervous system, elimination of functional disorders of the somatic and autonomic nervous systems in patients with alcoholism during the period of abstinence.

Special instructions

May give a positive result during doping control.

Active ingredient

Meldonium

Composition

Active substance:

Meldonium dihydrate (trimethylhydrazinium propionate dihydrate) – 250 mg.

Excipients:

potato starch,

colloidal silicon dioxide (aerosil),

calcium stearate.

Contraindications

Hypersensitivity to the drug, increased intracranial pressure (in case of impaired venous outflow and intracranial tumors), pregnancy, lactation, age under 18 years (efficacy and safety have not been established).

Side Effects

Rarely – allergic reactions (redness of the skin, itching, swelling), dyspepsia, tachycardia, agitation, decreased blood pressure.

Interaction

Enhances the effect of coronary dilatants and some antihypertensive drugs, cardiac glycosides.

Storage conditions

In a dry place at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

4 years. Do not use after expiration date.

Manufacturer

Pharmstandard-Leksredstva, Russia