Maxitrol, eye drops 5 ml

Maxitrol – antibacterial topical, anti-inflammatory topical.

Pharmacodynamics

Neomycin – has a bactericidal effect by disrupting protein synthesis in the microbial cell. It is active against Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus viridans, Escherichia coli, Clersella pneumoniae, Proteus vulgaris, Aerobacter aerogenes, Haemophilus influenzae. Little effective against streptococci as well. It is not effective against pathogenic fungi, viruses, anaerobic flora. Microorganisms develop resistance to neomycin slowly and to a small extent.

Polymyxin B. Mechanism of action is caused mainly by blockade of cytoplasmic membrane permeability of bacterial cells. It is active against P. aeruginosa, Aerobacter aerogenes, Escherichia coli, Kiersella pneumoniae, Koch-Weeks bacillus.

Dexamethasone is a GCS. It has anti-inflammatory, anti-allergic and desensitizing effects. It has an anti-exudative effect. Dexamethasone effectively suppresses inflammatory processes.

The combination of dexamethasone with antibiotics reduces the risk of developing an infectious process.

Pharmacokinetics

When used topically, systemic absorption is low.

Indications

Infections of the eye and its appendages:

Active ingredient

Composition

Active substances:

Neomycin sulfate 3500 IU;

Polymyxin B sulfate 6000 IU;

dexamethasone 1 mg;

Excipients:

hydroxypropyl methylcellulose – 0.5%,

polysorbate 20;

neutral additives;

distilled water;

Conservative:

Benzalkonium chloride – 0.004%.

How to take, the dosage

Into the conjunctival sac.

In mild infectious process 1-2 drops in the conjunctival sac 4-6 times a day.

In acute severe infectious process 1-2 drops in the conjunctival sac every 60 minutes, the frequency of instillation of the drug decreases as the inflammation decreases. The bottle of drops should be shaken before use.

Interaction

If used with other topical ophthalmic drugs, the interval between applications should be at least 10 minutes.

Interaction with other drugs is currently unknown.

Special Instructions

The bottle must be closed after each use.

Contraindications

With caution is prescribed for glaucoma, cataracts.

Side effects

Local. Allergic reaction accompanied by itching and swelling of the eyelids and reddening of the conjunctiva. Side effects due to the steroid component: increase in intraocular pressure with possible subsequent development of glaucoma, optic nerve damage and visual fields (intraocular pressure monitoring is necessary when using the drug for more than 10 days); posterior subcapsular cataract, slowing of the healing process. Local use of steroids in diseases that cause thinning of the cornea or sclera may lead to corneal perforation.

Secondary infection

The development of secondary infection is seen after the use of combined drugs containing glucocorticosteroids in combination with antibiotics. With prolonged use of steroids the development of fungal infections of the cornea is possible. Occurrence of non-healing ulcers on the cornea after long-term treatment with steroids may indicate the development of fungal invasion. Secondary bacterial infection may arise as a consequence of suppression of the patient’s body defenses.

Pregnancy use

There is no sufficient experience in the use of the drug during pregnancy and lactation.

Pregnant use is possible when prescribed by a physician if the expected therapeutic effect exceeds the risk of possible side effects. The use of the drug should be discontinued while breastfeeding.

Per pediatric use

The safety and effectiveness of the drug in children have not been established.

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