Maalox, suspension 250 ml

Pharmgroup:

Antacid.

Pharmaceutical action:

Aluminum hydroxide and magnesium hydroxide neutralize free hydrochloric acid of gastric juice without causing its secondary hypersecretion. In addition, increase of gastric juice pH while taking Maalox® preparation leads to decrease of pepsin activity in gastric juice.

The drug also has adsorptive and coating effect, due to which the impact of damaging factors on the mucous membrane of the esophagus and the stomach is reduced.

Pharmacokinetics:

Magnesium hydroxide and aluminum hydroxide are considered topical antacids. Because of low absorption, they have no systemic action.

Indications

Peptic ulcer of the stomach and duodenum in the acute phase;
chronic gastroduodenitis with normal or increased secretory function in the acute phase;
acute gastroduodenitis;
hiatal hernia;
reflux esophagitis;
phenomena of dyspepsia (and their prevention) resulting from the use of certain medications (including NSAIDs, corticosteroids);
discomfort or pain in the epigastrium, heartburn due to errors in diet, excessive consumption of coffee, alcohol, nicotine.

Pharmacological effect

Pharmaceutical group:

antacid.

Pharmaceutical action:

Aluminum hydroxide and magnesium hydroxide neutralize free hydrochloric acid of gastric juice without causing its secondary hypersecretion. In addition, an increase in the pH of gastric juice when taking the drug Maalox® leads to a decrease in the activity of pepsin in gastric juice.

The drug also has an adsorbing and enveloping effect, which reduces the impact of damaging factors on the mucous membrane of the esophagus and stomach.

Pharmacokinetics:

Magnesium hydroxide and aluminum hydroxide are considered topical antacids. Due to low absorption they do not have a systemic effect.

Special instructions

A 2-hour interval should be observed between taking Maalox and other medications.

When prescribing the drug to children, the dosage regimen is determined individually; It is not recommended to use the drug in children under 12 years of age without consulting a doctor.

Active ingredient

Algeldrat, Magnesium hydroxide

Composition

15 ml of suspension contains:

Active substances:

aluminum hydroxide (in the form of gel) 525 mg;

magnesium hydroxide (in the form of gel) 600 mg;

Excipients:

concentrated hydrochloric acid – 21.3 mg,

citric acid monohydrate – 9.83 mg,

peppermint leaf oil – 1.89 mg,

mannitol – 37.5 mg,

methyl parahydroxybenzoate – 15 mg,

propyl parahydroxybenzoate – 7.5 mg,

sodium saccharinate – 4.21 mg,

sorbitol 70% – 214.29 mg,

hydrogen peroxide 30% – 9.75 mg,

purified water – 4746.59 mg.

Pregnancy

Contraindicated during pregnancy and breastfeeding.

Contraindications

Severe renal failure;
hypersensitivity to active substances and other components of the drug;
hypophosphatemia;
fructose intolerance (due to the presence of sorbitol in the drug);
children and adolescents up to 12 years of age.

Side Effects

Immune system disorders: unknown frequency – hypersensitivity reactions such as itching, urticaria, angioedema and anaphylactic reactions.

Gastrointestinal disorders: infrequently – diarrhea, constipation.

Metabolic and nutritional disorders: unknown frequency – hypermagnesemia, hyperaluminemia, hypophosphatemia (with long-term treatment or taking high doses, or when taking standard doses with low phosphate content in food), which can lead to increased bone resorption, hypercalciuria, osteomalacia.

Interaction

When taken simultaneously with Maalox, the absorption of tetracycline antibiotics, ciprofloxacin, ofloxacin, digoxin, indomethacin, acetylsalicylic acid (and other salicylates), histamine H2 receptor blockers, beta-blockers, aminazine, diflunisal, isoniazid, phenytoin, phosphorus-containing drugs is reduced. drugs.

With simultaneous use, Maalox may increase the level of quinidine in the blood plasma, which increases the risk of overdose.

Overdose

Symptoms of acute overdose with a combination of aluminum hydroxide and magnesium salts include diarrhea, abdominal pain and vomiting.

In patients at risk, taking high doses of the drug may cause or worsen intestinal obstruction or intestinal obstruction.

Treatment: aluminum and magnesium are excreted in the urine. Treatment of acute overdose is carried out by replacing fluid loss and forced diuresis. Patients with renal failure require hemodialysis or peritoneal dialysis.

Storage conditions

At a temperature not higher than 25°C.

Shelf life

3 years

Manufacturer

Opella Healthcare Italy S.R.L., Italy