Lozarel Plus, 12.5mg+50 mg 30 pcs

LOZAREL is an antihypertensive agent.

It is a non-peptide blocker of angiotensin II receptors. It has high selectivity and affinity to AT1 receptors (with the participation of which the main effects of angiotensin II are realized).

Blocking these receptors losartan prevents and eliminates vasoconstrictor effect of angiotensin II, its stimulating effect on adrenal aldosterone secretion and some other effects of angiotensin II.

It is characterized by prolonged action (24 hours or more) due to the formation of its active metabolite.

Indications

Arterial hypertension.

Reduction of the risk of associated cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy, manifested by a decrease in the combined incidence of cardiovascular mortality, stroke and myocardial infarction.

Renal protection in patients with type 2 diabetes with proteinuria – slowing the progression of renal failure, manifested by a decrease in the frequency
of hypercreatininemia, the frequency of developing a terminal stage of CKD, requiring hemodialysis or renal transplantation,
mortality rates, as well as reducing proteinuria.

Chronic heart failure in ineffective treatment with ACE inhibitors.

Active ingredient

Composition

1 tablet contains:

Active ingredient:

lozartan potassium 50 mg.

Associates:

microcrystalline cellulose,

lactose monohydrate,

Pregelatinized starch,

Silica colloidal anhydrous,

Magnesium stearate.

Composition of the film coating:

Hypromellose, hyprolose, macrogol 400, titanium dioxide (E171), talc.

How to take, the dosage

The average oral dose is 50 mg once daily

If necessary, the dose can be decreased to 25 mg/day or increased to 100 mg/day, in the latter case it can be used 2 times/day.

Interaction

When concomitant use with diuretics in high doses, arterial hypotension is possible.

Concomitant use with potassium preparations, potassium-saving diuretics increases the risk of hyperkalemia.

Concomitant use with indomethacin may decrease the effectiveness of losartan.

Lithium intoxication has been reported with lithium carbonate.

Concomitant use with orlistat decreases the antihypertensive effect of losartan, which may result in a significant increase in BP, development of a hypertensive crisis.

Concomitant use with rifampicin increases the clearance of losartan and decreases its efficacy.

Special Instructions

RaAC medications may increase serum urea and creatinine concentrations in patients with bilateral renal artery stenosis or renal artery stenosis of the uniciliary artery.

In patients with dehydration (e.g., those treated with high doses of diuretics), symptomatic arterial hypotension may occur at the beginning of treatment with Lozarel (dehydration should be corrected before prescription of Lozarel or treatment should be started at a lower dose).

Physical potassium should be monitored regularly in patients taking long-term treatment with Lozarel.

Pediatric use

The safety and effectiveness in children has not been established.

Impact on driving and operating machinery

Lozartan does not affect the ability to drive or operate machinery.

Contraindications

Pregnancy, lactation, hypersensitivity to losartan.

Side effects

The side effects are usually mild and transient and do not require discontinuation of treatment.

Frequency determination of adverse reactions: very common (>10%), common (>1% 0.1% 0.01% < 0.1%) and very rare, including individual reports (< 0.01%).

Cardiovascular system: sometimes – orthostatic hypotension (dose-dependent), nasal bleeding, palpitations, tachycardia, bradycardia, arrhythmias, angina pectoris, myocardial infarction, vasculitis.

Gastrointestinal tract: frequently – nausea, diarrhea, dyspeptic symptoms, abdominal pain; sometimes – anorexia, taste disorder, dry mouth, toothache, vomiting, flatulence, gastritis, constipation, hepatitis, liver function disorder.

Dermatological reactions: sometimes – dry skin, erythema, subcutaneous hemorrhages, photosensitization, increased sweating, alopecia.

Allergic reactions: sometimes – hives, skin rash, itching, angioedema.

Hematopoietic system: sometimes Рanemia, thrombocytopenia, eosinophilia, thrombocytopenic purpura (Sch̦nlein-Henoch disease).

Muscular system disorders: frequently – cramps, myalgia, pain in back, chest, legs; sometimes – arthralgia, arthritis, fibromyalgia; rarely – rhabdomyolysis.

CNS and sense organs: frequently – dizziness, asthenia, headache, fatigue, insomnia; sometimes – anxiety, sleep disturbance, somnolence, memory disorders, peripheral neuropathy, paresthesia, hypoesthesia, tremor, ataxia, depression, syncope, tinnitus, vision disorders, conjunctivitis, migraine.

Respiratory system disorders: often – nasal congestion, cough, upper respiratory tract infections, pharyngitis, dyspnea, bronchitis, nasal mucous membrane edema.

Urinary system disorders: sometimes – imperative urge to urinate, urinary tract infections, renal dysfunction.

Perior genital system disorders: sometimes – decreased libido, impotence.

Laboratory indices: often – hyperkalemia (potassium level in plasma more than 5.5 mmol/l); sometimes – increase of urea and residual nitrogen or creatinine in serum; very rarely – moderate increase of liver transaminases activity (ACT, ALT), hyperbilirubinemia.

Others: gout.

Overdose

Symptoms: marked BP decrease and tachycardia; bradycardia may develop as a result of parasympathetic (vagus) stimulation.

Treatment: forced diuresis, symptomatic therapy.

Hemodialysis is not effective because losartan and its active metabolite are not eliminated from the body by hemodialysis.

Similarities