Loratadine, tablets 10 mg 10 pcs

Loratadine is a blocker of H1-histamine receptors (long-acting).

Inhibits release of histamine and leukotriene C4 from mast cells.

Prevent development and ease the course of allergic reactions.

It has antihistamine, anti-allergic, antipruritic and antiexudative action.

Limits capillary permeability, prevents development of tissue edema, relieves smooth muscle spasm.

The anti-allergic effect develops within 30 minutes, reaches its maximum after 8-12 hours and lasts for 24 hours.

It does not affect the central nervous system and is not addictive (as it does not penetrate through the blood-brain barrier).

Pharmacokinetics

It is quickly and completely absorbed in the gastrointestinal tract.

The time to reach maximum concentration is 1.3-2.5 h; food intake slows it down by 1 h. Maximum concentration in the elderly is increased by 50%, with alcoholic liver damage depending on the severity of the disease.

The binding to plasma proteins is 97%. Metabolized in the liver with the formation of the active metabolite descarboethoxyloratadine with the participation of cytochrome P450 isoenzymes, CYP3A4 and to a lesser extent CYP2D6.

The equilibrium concentration of loratadine and the metabolite in plasma is reached on day 5 of administration. It does not penetrate the blood-brain barrier.

The elimination half-life of loratadine is 3-20 h (mean 8.4), of active metabolite – 8.8-92 h (mean 28 h); in elderly patients – respectively 6.7-37 h (mean 18.2 h) and 11-38 h (17.5 h).

In alcoholic liver damage the half-life increases depending on the severity of the disease. It is excreted by the kidneys and with the bile.

In patients with chronic renal insufficiency and with hemodialysis the pharmacokinetics is practically unchanged.

Indications

Seasonal and year-round allergic rhinitis, conjunctivitis, pollinosis, urticaria (including chronic idiopathic).including chronic idiopathic), Quincke’s edema, allergic pruritic dermatoses; pseudoallergic reactions, allergic reactions to insect bites, itching of various etiologies.

Active ingredient

Composition

Active ingredient:

Loratadine 10 mg;

Associates:

Lactose (milk sugar) – 77.5 mg,

Calcium stearate – 1.0 mg,

p> Potato starch – 10.0 mg,

Sodium croscarmellose (primellose) – 1.5 mg

How to take, the dosage

Ingestion.

Adults and children over 12 years of age: 10 mg (1 tablet) once daily. The daily dose is 10 mg.

Children from 3 to 12 years of age: 5 mg (1/2 tablet) once daily. The daily dose is 5 mg.

In children with a body weight of more than 30 kg – 10 mg of the drug once a day. The daily dose is 10 mg.

Interaction

Ethanol reduces the effectiveness of loratadine.

Eritromycin, cimetidine, ketoconazole, when combined with loratadine increase plasma concentrations of loratadine without causing clinical manifestations and without affecting ECG.

Microsomal oxidation inducers (phenytoin, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) decrease the effectiveness of loratadine.

Special Instructions

Loratadine should be discontinued 48 hours prior to skin testing because antihistamines may interfere with diagnostic test results.

Loratadine has not been found to adversely affect the ability to drive or perform other activities requiring increased concentration.

In very rare cases, however, some patients experience drowsiness while taking loratadine, which may affect their ability to drive and operate machinery.

Synopsis

Contraindications

Hypersensitivity. Pregnancy, lactation, children under 3 years of age.

With caution: hepatic insufficiency.

Side effects

The undesired phenomena listed below occurred with a frequency of ≥2% when using loratadine and with approximately the same frequency as with placebo (“pacifier”).

In adults: headache, fatigue, dry mouth, drowsiness, gastrointestinal disorders (nausea, gastritis), and allergic reactions as a rash.

In addition, there have been rare reports of anaphylaxis, alopecia, impaired liver function, palpitations, and tachycardia.

In children rarely: headache, nervousness, sedation.

Overdose

Symptoms: drowsiness, tachycardia, headache. In case of overdose seek medical attention.

Treatment: induction of vomiting, gastric lavage, taking activated charcoal.

Pregnancy use

The use is possible only if the expected benefit to the mother exceeds the potential risk to the fetus.

Loratadine is excreted with the breast milk. Breast-feeding should be discontinued if it is necessary during lactation.

Similarities