Loperamide-Acrihin, capsules 2 mg 20 pcs

Loperamide, by binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons via guanine nucleotides), reduces intestinal smooth muscle tone and motility (due to inhibition of acetylcholine and PG release).

Indications

Diarrhea of ​​various origins (acute and chronic), regulation of stool in patients with ileostomy.

Pharmacological effect

Loperamide, by binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (due to inhibition of the release of acetylcholine and PG).

Special instructions

If there is no effect after 2 days of using Loperamide, you should consult a doctor.

If constipation or bloating develops during treatment, loperamide should be discontinued. In patients with impaired liver function, careful monitoring for signs of toxic damage to the central nervous system is necessary.

During the treatment of diarrhea, it is necessary to replace the loss of fluid and electrolytes.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Loperamide

Composition

Active ingredient:

loperamide hydrochloride 2 mg;

Excipients:

corn starch;

milk sugar;

talc;

Aerosil;

magnesium stearate.

Contraindications

colitis in the acute stage
acute dysentery
constipation
intestinal obstruction

Side Effects

Allergic reactions (skin rash), drowsiness or insomnia, dizziness, hypovolemia, electrolyte disturbances; dryness of the oral mucosa, intestinal colic, gastralgia, abdominal pain or discomfort, nausea, vomiting, flatulence.

Rarely – urinary retention, extremely rarely – intestinal obstruction.

Interaction

Opioid analgesics increase the risk of severe constipation.

Overdose

Symptoms: depression of the central nervous system (stupor, loss of coordination, drowsiness, miosis, muscle hypertension, respiratory depression), intestinal obstruction.

Treatment: antidote – naloxone; Given that the duration of action of loperamide is longer than that of naloxone, repeated administration of the latter is possible.

Symptomatic treatment: activated carbon, gastric lavage, artificial ventilation.

Medical supervision is required for at least 48 hours.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

Akrikhin JSC, Russia