Loperamide-Acrihin, capsules 2 mg 10 pcs

Pharmacodynamics.

Loperamide, by binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces intestinal smooth muscle tone and motility (by inhibiting the release of acetylcholine and prostaglandins).

Slows down peristalsis and increases the time of passage of intestinal contents. It increases tonicity of anal sphincter, promotes retention of feces and reduces urges to defecation. The action develops quickly and lasts 4-6 hours.

Pharmacokinetics.

In oral administration absorption is 40%. Maximum plasma concentration is reached 2.5 h after taking the capsules. Binding with plasma proteins (mainly with albumin) is 97%. It does not penetrate through the blood-brain barrier.

It is almost completely metabolized by the liver through conjugation. Half-life is 9-14 hours (average 9.8 hours). It is excreted mainly with the bile, a small part is excreted by the kidneys (as conjugated metabolites).

Indications

Active ingredient

How to take, the dosage

In adults with acute diarrhea, 2 capsules (4 mg) of Loperamide-Acrichine are prescribed initially, then 1 capsule (2 mg) after each act of defecation in case of liquid stools. The highest daily dose is 8 capsules (16 mg).

In chronic diarrhea, adults are prescribed 4 mg/day. The maximum daily dose is 16 mg.

In acute diarrhea, children over 6 years of age are given an initial dose of 2 mg and then 2 mg after each act of defecation in case of loose stools. The maximum daily dose is 4 capsules (8 mg).

In chronic diarrhea, children over 6 years of age are prescribed Loperamide-Acrichine in a daily dose of 2 mg. The maximum daily dose is 6 mg per 20 kg.

The drug should be discontinued after normalization of stools or if stools are absent for more than 12 hours.

Special Instructions

In children under 6 years of age it is not recommended to prescribe in capsules.

If constipation or bloating develops during treatment, Loperamide-Acrichine should be discontinued. In patients with liver dysfunction, careful monitoring of signs of toxic damage to the central nervous system is necessary. The loss of fluids and electrolytes must be replenished during treatment of diarrhea.

During treatment, caution should be exercised when driving motor vehicles and engaging in other potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Side effects

Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, colic, gastralgia, pain or discomfort in the stomach, nausea, vomiting, flatulence are possible.

Rarely – urinary retention, extremely rare – intestinal obstruction.

Overdose

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