Lomflox, 400 mg 5 pcs

Lomefloxacin is a synthetic antimicrobial drug of fluoroquinolone group with a broad spectrum of bactericidal action. It blocks bacterial DNA-hyruase by forming a complex with its tetramer and disrupts DNA transcription and replication, leads to the death of the microbial cell.

It is active against Gram-negative and Gram-positive microorganisms: Gram-negative aerobes (Citrobacter diversus and freundii , Enterobacter cloacaae, aerogenes and agglomerans, Escherichia coli , Haemophilus influenzae, parainfluenzae, Klebsiella pneumoniae, oxytoca and ozaenae, Moraxella catarralis, Proteus mirabilis, stuartii, vulgaris, Pseudomonas aeruginosa, Morganella morganii, Legionella pneumophilla, Salmonella spp., Shigella spp. , Providencia rettgeri, Serratia liquefaciens and marcescens , Neisseria gonorrhoeae , Neisseria meningitidis), Gram-positive aerobes (Staphylococcus saprophyticus, aureus and epidermidis ), chlamydia, Mycobacterium tuberculosis (both extra and intracellular), some mycoplasma strains and uroplasm. In an acidic environment the efficacy decreases, resistance develops slowly. It has a pronounced postantibiotic effect. Streptococci (most groups A, B, D, G), Streptococcus pneumoniae, Pseudomonas cepacia, Ureaplasma urealyticum, Mycoplasma hominis and anaerobes are resistant to lomefloxacin.

Pharmacokinetics

Lomefloxacin is almost completely absorbed from the gastrointestinal tract after oral administration. When administered in a dose of 400 mg in the blood plasma Cmax is reached after 1.5-2 hours and is 3-5.2 mg/l. When administering the drug at a dose of 400 mg/day lomefloxacin concentration exceeds MPC for most pathogens for at least 12 hours.

The binding to plasma proteins is 10%. Lomefloxacin penetrates rapidly into most tissues. Concentrations in tissues and body fluids are generally 2-7 times higher than in plasma, especially in pulmonary macrophages, prostate tissues and urine. T1/2 of lomefloxacin is 7-9 h. About 70-80% is excreted unchanged in the urine within 24 hours.

In patients with impaired renal function the T1/2 of lomefloxacin is significantly increased.

Indications

Active ingredient

Composition

1 coated tablet contains 400 mg of lomefloxacin hydrochloride

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How to take, the dosage

In urinary tract infections, 400 mg once daily for up to 10 days (uncomplicated forms) or 10-14 days (complicated forms) is usually prescribed.

In acute gonorrhea, 600 mg once daily; in chronic gonorrhea, 600 mg once daily for 5 days.

In urogenital chlamydia, including mixed bacterial-chlamydial infection, a dose of 400-600 mg once daily for 28 days is used.

In acute and chronic purulent infections of soft tissues, infected wounds, the dose is 400 mg once daily for 5-14 days.

In ostiomyelitis it is used in doses of 400-800 mg per day. The course of treatment is up to 14 days.

For prophylaxis before transurethral surgery, a single dose of 400 mg may be prescribed 2-6 hours before the procedure.

In a severe course of cholera, 400 mg once daily for 5 days.

In case of tuberculosis it is used in a dose of 400 mg 2 times a day for 14 to 28 days, if necessary for a longer period.

In lower respiratory tract infections, acute bronchitis, bronchopneumonia, it is prescribed in a dose of 400 mg per day for 10 days.

In elderly patients, in most cases, the usual doses can be prescribed if they have a creatinine clearance of at least 40 ml/min.

In patients with renal and hepatic impairment with a creatinine clearance of less than 40 mL/min, doses should be modified according to the degree of renal impairment. The initial dose of 400 mg should be followed by doses of 200 mg once daily during the course of treatment. There is no need to reduce the dose for patients with cirrhosis if renal function is adequate. The drug is taken regardless of meals.

Interaction

Antipepsin-acting polysaccharides or antacids containing magnesium or aluminum should not be used within 4 hours before and 2 hours after taking Lomefloxacin, since this reduces its bioavailability. Mineral supplements or vitamins containing iron or minerals should not be taken within 2 hours of taking . There is evidence that H2 antagonists (cimetidine, ranitidine) may interfere with the elimination of quinolones, resulting in increased elimination half-lives and POC.

Unlike other quinolones, it does not inhibit theophylline metabolism, so recalculation of theophylline dose is not necessary.

The quinolones may aggravate the effect of the oral anticoagulants warfarin or its derivatives, if prescribed concomitantly. Prothrombin or other coagulation parameters should be checked and monitored.

There is no cross-resistance with penicillins, cephalosporins, aminoglycosides, co-trimoxazole, metronidazole.

Lomflox is used in combination therapy with isoniazid, pyrazinamide, streptomycin, and ethambutol.

Special Instructions

Caution is used in patients with severe cerebral atherosclerosis, patients with epilepsy and other CNS diseases.

In case of symptoms such as seizures, agitation, photophobia, confusion, hallucinations during treatment, the drug should be stopped.

During treatment, it is recommended to avoid prolonged exposure to sunlight or ultraviolet light. If used during lactation, discontinuation of breastfeeding should be considered.

It may cause dizziness and impaired attention, so should not engage in activities requiring coordination (working with complex equipment, driving a car).

At the level of other quinolones, it may interfere with caffeine metabolism (tea/coffee), decreasing clearance, prolonging the half-life and increasing the symptoms of caffeine overdose.

An increase in fluid intake is necessary during treatment.

Contraindications

Hypersensitivity to Lomflox.

Side effects

Rarely: nausea, diarrhea, epigastric pain, headache, sleep disturbances, mood swings, agitation, tremor, depression.

In excessive exposure to ultraviolet rays, a moderate photosensitization effect may be observed. In this case, treatment should be discontinued. May cause arthropathy in the growing body. Allergic reactions in the form of skin rash and other manifestations are possible.