Lincomycin, capsules 250 mg 20 pcs

Pharmacotherapeutic group
Antibiotic lincosamide

Pharmacokinetics

Absorption – 30-40% (eating slows down the rate and extent of absorption). Time of reaching maximal drug concentration in plasma (TS max) – 2-3 hours. It penetrates well into lung, liver and kidney tissues, through the placental barrier, into breast milk; in high concentrations it is found in bone tissue and joints. Through the blood-brain barrier (BBB) lincomycin penetrates only slightly; in meningitis its permeability increases.

Partially metabolized in the liver. The half-life of the drug (T1/2) is 5 hours. It is excreted unchanged and as metabolites in the bile and kidneys.

Pharmacodynamics

The antibiotic produced by Streptomyces lincolnensis has a bacteriostatic effect. Inhibits protein synthesis of bacteria due to reversible binding to 50S ribosome subunit, disrupts formation of peptide bonds. It is active against Gram-positive cocci (Staphylococcus spp., Streptococcus spp. including Streptococcus pneumoniae); Haemophilus influenzae; Bacillus anthracis, Mycoplasma spp., Bacteroides spp., Corynebacterium diphtheriae, Clostridium perfringens, Clostridium tetani.

Effective against Staphylococcus spp. resistant to penicillin, tetracyclines, chloramphenicol, streptomycin, cephalosporins (30% of erythromycin-resistant Staphylococcus spp. have cross-resistance to lincomycin). It has no effect on Enterococcus spp (including Enterococcus faecalis), Gram-negative microorganisms, fungi, viruses, protozoa; erythromycin has inferior activity against spore-forming anaerobes, Neisseria spp, Corynebacterium spp. Optimum activity is in alkaline environment (pH 8-8.5). Resistance to lincomycin develops slowly. In high doses it has a bactericidal effect.

Indications

Active ingredient

Composition

Composition per capsule

The active ingredient

Lincomycin hydrochloride (in terms of lincomycin) – 0.25 g,

Additional substances

Potato starch, sucrose./p>

Excipients

Potato starch, sucrose.

Solid gelatin capsules – gelatin, titanium dioxide, methylhydroxybenzoate, propylhydroxybenzoate, acetic acid.

How to take, the dosage

Overly, 1-2 hours before a meal or 2-3 hours after a meal 2-3 times a day at intervals of 8-12 hours. For adults daily dose is 1-1.5 g, single dose – 0.5 g. For children the daily dose is 30-60 mg/kg.

The duration of treatment depending on the form and severity of the disease is 7-14 days (with osteomyelitis – 3 weeks or more).

Interaction

Special Instructions

With long-term treatment, periodic monitoring of liver transaminase activity and renal function is necessary. Administration to patients with hepatic insufficiency is allowed only for “vital” indications. If signs of pseudomembranous enterocolitis appear (diarrhea, leukocytosis, fever, abdominal pain, excretion of blood and mucus with feces) in mild cases it is enough to cancel the drug and appoint ion exchange resins (colestyramine); in severe cases compensation of fluid, electrolyte and protein loss is indicated, vancomycin – orally, in daily dose 0,5-2 g (3-4 intakes) for 10 days or bacitracin.

In case of prolonged or repeated courses, treatment should be carried out under control of liver and kidney function.

Contraindications

Hypersensitivity, pregnancy (except when necessary for “vital” indications), severe hepatic and/or renal failure; lactation, children under 3 years of age (for capsules).

With caution

Fungal diseases of the skin, oral mucous membranes, the vagina.