Lincomycin hydrochloride, 300 mg/ml 1 ml 10 pcs.

Skin infections, Lung inflammation (pneumonia), Boils, Osteomyelitis, Pyoderma, Purulent wounds, Otitis media

Lincomycin hydrochloride, solution for intravenous and intramuscular administration, is indicated for treatment of severe infections caused by susceptible strains of microorganisms (see section “Pharmacological properties”). Its use should be reserved for patients in whom penicillin cannot be used or who are allergic to penicillin.

Because of the risk of pseudomembranous colitis associated with lincomycin, the severity of the infection and the possibility of using less toxic drugs (e.g., erythromycin) should be considered when prescribing lincomycin.

Surgical procedures may be performed in conjunction with antimicrobial therapy.

The simultaneous use of lincomycin with other antimicrobial drugs is possible if indicated.

Lincomycin should not be used in mild bacterial infections or viral diseases.

In order to reduce the development of drug-resistant bacteria and to maintain the effectiveness of lincomycin and other antibacterial agents, lincomycin should only be used to treat or prevent infections with a proven or suspected susceptible microorganism. If data on the type and sensitivity of the infectious agent are available, they are used to select or modify antibiotic therapy. In the absence of such data, local knowledge of the epidemiology and sensitivity of the microorganisms may be used for empirical treatment.

Indications

Lincomycin hydrochloride, a solution for intravenous and intramuscular administration, is indicated for the treatment of severe infections caused by sensitive strains of microorganisms (see section “Pharmacological properties”). Its use should be reserved for patients who are unable to use penicillin or are allergic to penicillin.

Due to the risk of developing pseudomembranous colitis associated with lincomycin, when prescribing lincomycin, the severity of the infection and the possibility of using less toxic drugs (for example, erythromycin) should be taken into account.

Surgical procedures may be performed in combination with antimicrobial therapy.

It is possible to use lincomycin simultaneously with other antimicrobial drugs if indicated.

Lincomycin should not be used for mild bacterial infections or viral diseases.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of lincomycin and other antibacterial agents, lincomycin should be used only for the treatment or prevention of infections with a proven or suspected susceptible organism. If data is available on the type and sensitivity of the infectious agent, they are used to select or change antibacterial therapy. In the absence of such data, local knowledge of the epidemiology and susceptibility of microorganisms can be used for empirical treatment.

Pharmacological effect

Pharmacodynamics

Special instructions

To avoid the development of thrombophlebitis and aseptic necrosis, it is better to administer it deeply intramuscularly.

Active ingredient

Lincomycin

Composition

Active substance:

lincomycin (in the form of lincomycin hydrochloride) – 300 mg;

excipients:

disodium edetate,

sodium hydroxide 1 M solution,

water for injections.

Contraindications

Hypersensitivity to lincomycin, clindamycin and auxiliary components of the drug, pregnancy (except for cases when it is necessary for “vital” indications), lactation period, early infancy (up to 1 month).

Side Effects

From the digestive system: nausea, vomiting, diarrhea, epigastric pain, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of liver transaminases, with long-term use – candidiasis of the gastrointestinal tract, pseudomembranous colitis.

Interaction

Physically compatible: 5% dextrose solution, 10% dextrose solution, 5% dextrose and 0.9% sodium chloride, 10% dextrose and 0.9% sodium chloride, Ringer’s solution, infusion solutions with B vitamins, infusion solutions with B vitamins and ascorbic acid, penicillin, cephalothin, tetracycline, cephaloridine, colistimethate sodium, ampicillin, methicillin, chloramphenicol, polymyxin sulfate. Physically incompatible: novobiocin, kanamycin.

Antagonism between lincomycin and erythromycin was observed in in vitro studies. Due to potential clinical significance, these drugs should not be used together.

Antidiarrheal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours). Lincomycin has the property of blocking neuromuscular conduction, so caution should be exercised when used together with neuromuscular conduction blockers. Strengthens the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and respiratory arrest.

Please note that determinations of compatibility and incompatibility have been established based on physical observations only and not chemical analyses. Adequate clinical evaluation of the safety and effectiveness of these combinations has not been performed.

Overdose

Symptoms: increased severity of side effects, diarrhea, colitis.

Treatment: symptomatic therapy. A specific antidote to lincomycin is unknown. Hemodialysis and peritoneal dialysis are ineffective.

Storage conditions

In a place protected from light at a temperature of 15 ºС to 25 ºС.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiration date stated on the package.

Manufacturer

Belmedpreparaty, Belarus