Libexin, tablets 100 mg 20 pcs

Prenoxdiazine is an antitussive agent of peripheral action.

The drug Libexin blocks the peripheral links of the cough reflex due to the following effects:

– local anesthetic action, which reduces irritability of peripheral sensitive (cough) airway receptors;

– bronchodilator effect, due to which the stretching receptors, participating in the cough reflex, are inhibited;

– a slight decrease of respiratory center activity (without suppression of respiration). The anti-coughing effect of the drug is approximately equal to that of codeine.

Prenoxdiazine is not addictive and not addictive. In chronic bronchitis an anti-inflammatory effect of Prenoxdiazine has been noted. Prenoxdiazine does not affect CNS function, except for a possible indirect anxiolytic effect.

Indications

Unproductive cough of any origin:

• cough of the upper respiratory tract, influenza, acute and chronic bronchitis, pneumonia, emphysema;
• nocturnal cough in patients with heart failure;
• preparing patients for bronchoscopic or bronchographic examination.

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Active ingredient

Prenoxdiazine

Composition

Active ingredient:

prenoxdiazine hydrochloride 100 mg;

Associates:

glycerol (glycerin);

magnesium stearate;

talc; <

povidone;

corn starch;

lactose monohydrate.

How to take, the dosage

Ingestion. The tablets are swallowed without chewing (to avoid anesthesia of the oral mucosa).

The average dose for adults is 100 mg 3 or 4 times a day (1 tablet 3-4 times a day). In more severe cases, the dose may be increased to 200 mg 3-4 times or 300 mg 3 times a day (2 tablets 3-4 times a day or 3 tablets 3 times a day).

The average dose for children, depending on age and body weight, is 25-50 mg 3 or 4 times a day (1/4-1/2 tablets 3-4 times a day).

The maximum single dose for children is 50 mg (1/2 tablet), for adults 300 mg (3 tablets). The maximum daily dose for children is 200 mg (2 tablets), for adults 900 mg (9 tablets).

In preparation for bronchoscopy, a dose of 0.9-3.8 mg/kg is combined with 0.5 -1 mg atropine 1 hour before the procedure.

Interaction

It is not recommended to combine the drug with mucolytic and expectorants, because it may hinder secretion of sputum, liquefied by the latter.

There are no preclinical or clinical data about interactions with other drugs.

Special Instructions

The drug may cause gastrointestinal complaints in patients with lactose intolerance because each tablet contains 0.38 mg of lactose.

Impact on the ability to drive vehicles and perform hazardous work.

The use of the drug in high doses may slow reaction time; therefore, when taking the drug in high doses, the question of ability to drive a vehicle or perform hazardous work must be solved individually.

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Contraindications

• high sensitivity to the drug;
• diseases associated with profuse bronchial secretion;
• Galactose intolerance, lactase deficiency, or glucose-galactose malabsorption.

With caution: childhood.

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Side effects

Allergic reactions: rare – skin rash; angioedema; unknown frequency – bronchospasm.

Gastrointestinal disorders: rare – dry mouth or throat; anesthesia (temporary numbness and loss of sensitivity) of the oral mucosa; often – pain in the stomach; constipation; nausea.

Nervous system disorders (when using the drug in high doses): unknown frequency – mild sedation; fatigue.

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