Libexin Muco, 20 mg/ml syrup 125 ml

Carbocysteine, being a mucolytic, acts on the gel phase of the endobronchial secretion, breaking disulfide bridges of glycoproteins and thus reducing viscosity and increasing elasticity of the secretion.

Carbocysteine activates sialic transferase – an enzyme of bocalytic cells of the bronchial mucosa, normalizes the quantitative ratio of acidic and neutral sialomucins, promotes mucous membrane regeneration, normalizes its structure, stimulates the activity of ciliated epithelium, restores the secretion of immunologically active IgA (specific protection), improves mucociliary clearance.

Pharmacokinetics

Carbocysteine is rapidly absorbed after oral administration, reaching maximum serum levels after 2 hours.

The bioavailability is low (less than 10% of the dose taken) as a result of possible rapid passage through the liver.

The elimination half-life is about 2 hours. It is excreted mainly by the kidneys together with metabolites.

Indications

Tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis, inflammatory diseases of the middle ear, nose and paranasal sinuses – rhinitis, otitis media, sinusitis; preparing the patient for bronchoscopy or bronchography.

Pharmacological effect

Carbocysteine, being a mucolytic, has an effect on the gel phase of endobronchial secretion, breaking the disulfide bridges of glycoproteins and, thus, reducing the viscosity and increasing the elasticity of the secretion.

Carbocysteine ​​activates sialic transferase, the enzyme of goblet cells of the bronchial mucosa, normalizes the quantitative ratio of acidic and neutral sialomucins, promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliated epithelium, restores the secretion of immunologically active IgA (specific protection), improves mucociliary clearance.

Pharmacokinetics

Carbocisteine ​​is rapidly absorbed after oral administration, reaching maximum serum levels after 2 hours.

Bioavailability is low (less than 10% of the dose taken) as a result of possible rapid passage through the liver.

The half-life is about 2 hours. It is excreted primarily by the kidneys along with metabolites.

Special instructions

The alcohol content of Libexin Muco® (for adults) is 1.64 vol.%, i.e. 0.2 g alcohol per measuring cup. May be dangerous for people with liver disease, alcoholism, epilepsy, brain injury or disease, and pregnant women.

When prescribing Libexin Muco® to patients with diabetes mellitus or patients on a low-carbohydrate diet, the sucrose content should be taken into account – 6 g per measuring cup of syrup for adults or 3.5 g per measuring spoon of syrup for children.

When patients follow a salt-free or low-salt diet, the sodium content (97 mg) per measuring cup should be taken into account.

Impact on the ability to drive a car or perform work that requires increased speed of physical and mental reactions.

Impaired speed of psychomotor reactions associated with the presence of alcohol in the drug can pose a danger when driving a car or working with machinery.

Active ingredient

Carbocysteine

Composition

100 ml of syrup contains:

Active substance:

carbocisteine ​​2 g;

Excipients:

sucrose – 70 g;

methyl parahydroxybenzoate – 0.15 g;

vanillin – 0.05 g;

crimson dye Ponceau 4R (cochineal red A – E124) – 0.005 g;

raspberry flavoring – 1 ml;

cherry flavoring – 0.5 ml;

sodium hydroxide – q.s. to pH 6.1–6.3;

purified water – up to 100 ml.

Contraindications

Peptic ulcer of the stomach and duodenum in the acute stage;
chronic glomerulphritis (in the acute phase), cystitis;
pregnancy;
children under 2 years of age;
hypersensitivity to carbocisteine ​​or other components of the drug.

With caution, a history of gastric and duodenal ulcers, lactation period.

Side Effects

From the gastrointestinal tract: sometimes – nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.

From the immune system: allergic skin rash and anaphylactic reactions, including urticaria, angioedema, exanthema, persistent drug erythema.

Skin and subcutaneous tissue disorders: isolated cases of bullous dermatitis, including Stevens-Johnson syndrome and erythema multiforme (exudative).

Allergic reactions: itching, urticaria, exanthema, angioedema.

Other: dizziness, weakness, malaise.

Interaction

Carbocysteine ​​increases the effectiveness of GCS and antibacterial therapy for inflammatory diseases of the upper and lower respiratory tract, and potentiates the bronchodilator effect of theophylline. The activity of carbocisteine ​​is weakened by antitussives and atropine-like drugs.

Due to the alcohol content, Libexin Muco® (for adults) is prescribed with caution with the following drugs: drugs that cause adverse reactions (fever, redness, vomiting, tachycardia) when taken simultaneously with alcoholic beverages – disulfiram, cefamandole, cefoperazone, latamoxef (cephalosporin antibiotics), chloramphenicol (phenicol antibiotic), chlorpropamide, glibenclamide, glipizide, tolbutamide (sulfamide antidiabetic drugs), griseofulvin (antifungal drug), nitro-5-imidazoles (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole, procarbazine (cytostatic); drugs that depress the central nervous system.

Overdose

Symptoms: gastralgia, nausea, diarrhea.

Treatment: symptomatic.

Storage conditions

At a temperature not exceeding 25 °C.

Shelf life

3 years

Manufacturer

Sanofi A.Nattermann & See GmbH, Germany