Levomycetin, tablets 250 mg 10 pcs

A broad-spectrum antibiotic. The mechanism of antimicrobial action is associated with disruption of microbial protein synthesis. It has a bacteriostatic effect. It is active against Gram-positive bacteria:
– Staphylococcus spp, Streptococcus spp.;
– Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp, Rickettsia spp.;
– is also active against Spirochaetaceae, some major viruses.
Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides.
Resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

For oral administration:
– infectious and inflammatory diseases caused by microorganisms sensitive to chloramphenicol, including: typhoid fever, paratyphoid fever, dysentery, brucellosis, tularemia, whooping cough, typhus and other rickettsioses;
– trachoma, pneumonia, meningitis, sepsis, osteomyelitis.

Pharmacological effect

Broad-spectrum antibiotic. The mechanism of antimicrobial action is associated with a violation of the synthesis of microbial proteins. Has a bacteriostatic effect. Active against gram-positive bacteria:
— Staphylococcus spp., Streptococcus spp.;
— gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.;
– also active against Spirochaetaceae and some large viruses.
Chloramphenicol is active against strains resistant to penicillin, streptomycin, and sulfonamides.
Resistance of microorganisms to chloramphenicol develops relatively slowly.

Special instructions

Chloramphenicol is not used in newborns, because the development of “gray syndrome” is possible (flatulence, nausea, hypothermia, gray-blue skin color, progressive cyanosis, dyspnea, cardiovascular failure).

Active ingredient

Chloramphenicol

Composition

1 tablet contains:

Contraindications

Blood diseases, severe liver dysfunction, deficiency of the enzyme glucose-6-phosphate dehydrogenase, skin diseases (psoriasis, eczema, fungal diseases); pregnancy, lactation, children up to 4 weeks of age (newborns), hypersensitivity to chloramphenicol, thiamphenicol, azidamphenicol.

Side Effects

From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia.

Interaction

With the simultaneous use of chloramphenicol with oral hypoglycemic drugs, an increase in the hypoglycemic effect is observed due to the suppression of the metabolism of these drugs in the liver and an increase in their concentration in the blood plasma.
When used simultaneously with drugs that inhibit bone marrow hematopoiesis, there is an increased inhibitory effect on the bone marrow.

Manufacturer

Irbitsky Chemical Plant, Russia