Levomycetin, eye drops 0.25% 10 ml

Levomycetin is a broad spectrum antibiotic; effective against many Gram-positive cocci (gonococci and meningococci), various bacteria (E. coli and Haemophilus influenzae, Salmonella, Shigella, Klebsiella, Serreria, Yersenia, Proteus), rickettsia, spirochetes and some major viruses. The drug is active against strains resistant to penicillin, streptomycin, sulfonamides. It is weakly active against acid-resistant bacteria, Pseudomonas aeruginosa, clostridium and protozoa.

It acts bacteriostatically. The mechanism of antibacterial action is connected with disruption of protein synthesis in microorganisms.

Drug resistance to the drug develops relatively slowly, and, as a rule, cross-resistance to other chemotherapeutic agents does not occur.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

To prevent increased suppressive effects on blood production, co-administration with sulfonamides is not recommended.

Special Instructions

Due to the high toxicity it is not recommended to use unnecessarily for the treatment and prevention of trivial infections, colds, influenza, pharyngitis, bacturia.

Severe complications of the hematopoietic system, as a rule, are associated with the use of high doses (more than 4 g/day) for a long time. Systematic monitoring of peripheral blood counts is necessary during treatment.

In fetus and newborn children the liver is not developed enough to bind chloramphenicol and the drug may accumulate in toxic concentration and lead to “gray syndrome”, therefore in children in the first months of life the drug is prescribed only with vital signs.

Patients who have previously been treated with cytostatic drugs or radiation therapy are used with caution.

Contraindications

Hypersensitivity, blood disorders, acute intermittent porphyria, marked renal and hepatic dysfunction, glucose-6-phosphate dehydrogenase deficiency, psoriasis, eczema, fungal skin diseases, period of infancy (up to 4 weeks) and early childhood.

Side effects

Local allergic reactions.

Overdose

Symptoms: “gray syndrome” in premature and newborn infants when treated with high doses (cause of development is accumulation of chloramphenicol due to immaturity of liver enzymes and its direct toxic effect on myocardium) – bluish-gray skin color, low body temperature, nonrhythmic breathing, no reactions, cardiovascular failure. Lethality is up to 40%.

Treatment: hemosorption, symptomatic therapy.

Pregnancy use

In pregnancy it is possible if the expected effect of therapy exceeds the potential risk to the fetus (adequate and strictly controlled studies on use during pregnancy have not been conducted, the ability of chloramphenicol to penetrate the placenta should be taken into account).

The FDA fetal category is C.

In oral administration, it penetrates the breast milk of breastfeeding women and may cause serious adverse reactions in breastfed infants. When applied topically, systemic absorption is possible. In this regard, breastfeeding women should stop either breastfeeding or use of the drug.

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