Levomycetin, 1% 25 ml

A broad spectrum antibiotic. The mechanism of antimicrobial action is associated with disruption of microbial protein synthesis.

It has a bacteriostatic effect. It is active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp.; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp, Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; also active against Spirochaetaceae, some major viruses.

Chloramphenicol is active against strains resistant to penicillin, streptomycin, sulfonamides.

The resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and limited deep), bedsores, trophic ulcers, wounds, boils.

Pharmacological effect

Pharmacotherapeutic group
Antibiotic

ATX code: 206АХ02

Pharmacological properties
The active ingredient of the drug is chloramphenicol, a broad-spectrum antibiotic with high antibacterial activity against pathogens of wound infections and various forms of purulent-inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic that disrupts the process of protein synthesis in the microbial cell (having good lipophilicity, it penetrates the bacterial cell membrane and is reversible
binds to subunit 505 of bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to disruption of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines and sulfonamides. Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelization.
Ineffective against acid-fast bacteria, anaerobes, Acinetobacter spp., Serattia marcescens.

Special instructions

During treatment, systematic monitoring of peripheral blood patterns is necessary. When applied to large surfaces with simultaneous intake of ethanol, the development of disulfiram-like reactions (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions) is possible.

Impact on the ability to drive vehicles and machinery

The use of the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, working with moving mechanisms).

Active ingredient

Chloramphenicol [D,L]

Composition

Active ingredient: Chloramphenicol (chloramphenicol) – 0.25g; 1g; 3g; 5g

Excipient: Ethanol (ethyl alcohol) 70% – up to 100ml.

Pregnancy

The use of the drug during pregnancy and breastfeeding is contraindicated.

Contraindications

Hypersensitivity to any of the components of the drug, inhibition of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, liver failure, renal failure, skin diseases (fungal diseases, psoriasis, eczema), pregnancy, breastfeeding period, neonatal period (up to 4 weeks).

With caution
Early childhood, previous treatment with cytotoxic drugs or radiation therapy.

Side Effects

Allergic reactions (skin rash, angioedema).
From the hematopoietic organs: thrombocytopenia, erythropenia, leukopenia, aplastic anemia, reticulocytopenia, granulocytopenia, agranulocytosis.
If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When used simultaneously with erythromycin, clindamycin, lincomycin, a mutual weakening of the effect is observed due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the 50S subunit of bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins. Simultaneous use with drugs that inhibit bone marrow hematopoiesis (sulfonamides, cytostatics) and radiation therapy increases the risk of side effects. If you are using the above or other medications (including over-the-counter medications), consult your doctor before using *Levomycetin*.

Overdose

To date, there have been no reports of cases of overdose when using the drug.

Storage conditions

Protected from light at a temperature of 15 to 25 ° C.
Keep out of the reach of children.

Shelf life

2 years. Do not use after the expiration date stated on the package.

Manufacturer

Tula pharmaceutical factory, Russia