Levocetirizine-Teva tablets, 5 mg 10 pcs.

The enantiomer of cetirizine; a competitive histamine antagonist; blocks H1-histamine receptors, affinity to which is 2 times higher than that of cetirizine.

It influences the histamine-dependent stage of allergic reactions; it reduces migration of eosinophils, decreases vascular permeability, limits the release of inflammatory mediators.

It prevents and facilitates allergic reactions, has antiexudative, antipruritic action; it has practically no anticholinergic and antiserotonic action. In therapeutic doses it practically has no sedative effect.

The action begins 12 minutes after a single dose in 50% of patients, within 1 hour in 95% of patients and lasts for 24 hours.

Indications

Symptomatic treatment of year-round and seasonal allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia); hay fever (pollinosis); urticaria, includingincluding chronic idiopathic urticaria; Quincke’s edema; allergic dermatoses accompanied by itching and rashes.

Active ingredient

Composition

1 tablet contains:

The active ingredient:

Levocetirizine 5 mg

How to take, the dosage

Overly, with meals or on an empty stomach with a small amount of water, without chewing.

The recommended dose is 5 mg (1 tablet) for adults and children over 6 years old, elderly patients (provided that kidney function is normal).

The course of treatment in case of polinosis is 1-6 weeks; in chronic diseases (year-round rhinitis, atopic dermatitis) – up to 18 months.

Interaction

Theophylline (400 mg/day) decreases total clearance of levocetirizine by 16%, while the kinetics of theophylline is not changed.

Co-administration with macrolides or ketoconazole did not cause significant changes in ECG.

Special Instructions

During treatment, it is necessary to refrain from potentially hazardous activities that require high concentration and rapid psychomotor reactions, as well as from drinking ethanol.

Contraindications

Hypersensitivity (including to piperazine derivatives), severe CKD (IQ less than 10 ml/min), pregnancy, lactation, children (under 6 years).
With caution. CKD, advanced age (decreased glomerular filtration is possible).

Side effects

Headache, drowsiness, dry mouth, fatigue, rarely – migraine, dizziness, dyspepsia, allergic reactions (angioedema, rash, urticaria, skin itching).

Overdose

Symptoms: drowsiness, in children – anxiety, irritability.

Treatment: gastric lavage, activated charcoal, symptomatic therapy. There is no specific antidote. Hemodialysis is not effective.

Similarities