Lercanorm, 20 mg 30 pcs.

Lercanidipine is a selective slow calcium channel blocker, a 1,4-dihydropyridine derivative, inhibits transmembrane flow of calcium ions into vascular smooth muscle cells. Lercanidipine is a racemic mixture of (+)R- and (-)S-enantiomers. The antihypertensive effect of lercanidipine, like other asymmetric 1,4-dihydropyridine derivatives, is mainly determined by the S-enantiomer.

Indications

Active ingredient

Composition

active ingredient: lercanidipine hydrochloride – 20.0 mg;

excipients: cellulose microcrystalline, 74.0 mg; lactose monohydrate, 70.0 mg; sodium carboxymethyl starch (sodium starch glycolate, type A), 20.0 mg; povidone K-30 – 9.0 mg; poloxamer – 5.0 mg; magnesium stearate – 2.0 mg;

film coating: [hypromellose, 3.0000 mg; hyprolose (hydroxypropyl cellulose), 1.1640 mg; talc, 1.1556 mg; titanium dioxide, 0.6522 mg; Iron oxide yellow (iron oxide) – 0.0282 mg] or [dry film coating mixture containing hypromellose (50%), hyprolose (hydroxypropylcellulose) (19.4%), talc (19.26%), titanium dioxide (10.87%) and iron oxide yellow (iron oxide) (0.47%)] – 6.0 mg.

How to take, the dosage

Ingestion.

Lercanorm is taken 10 mg once daily in the morning, at least 15 minutes before a meal, without chewing, with plenty of water.

Depending on the therapeutic effect and individual tolerance of the patient, the dose can be increased up to 20 mg. The therapeutic dose is adjusted gradually because the maximum antihypertensive effect develops approximately 2 weeks after starting the drug.

The effectiveness of the drug is unlikely to increase with increasing the dose more than 20 mg daily, at the same time the risk of side effects increases.

Use in elderly patients

Lercanorm does not require dose adjustment in elderly patients, but caution should be exercised when taking the drug, especially at the start of treatment.

Use in patients with renal or hepatic impairment

Lercanorm should be used with caution in patients with renal impairment
(CKR over 30 ml/min) or mild to moderate hepatic impairment. The initial dose is 10 mg per day. Increasing the dose to 20 mg per day should be carried out with caution. If the antihypertensive effect is too pronounced, the dose should be reduced.

Lercanorm is contraindicated in renal failure (CKR less than 30 ml/min) and in severe hepatic failure (see section “Contraindications”).

Interaction

Special Instructions

Contraindications

Side effects

Similarities