Legalon 140, 140 mg capsules 60 pcs

The milk thistle fruit dry extract is standardized for the content of silymarin.

Therapeutic effects of silymarin:

Detoxifying. The anti-toxic effect of silymarin has been found in studies in various models of liver damage, such as the pale grebe toxin phalloidin and alpha-amanitin, lanthanides, carbon tetrachloride, galactosamine, thioacetamide and the hepatotoxic FV3 virus.

Cytoprotective. Silymarin inhibits the penetration into the cell of some hepatotoxic substances (pale grebes venom).

Antioxidant. Due to the ability of silymarin to bind free radicals, it has antioxidant activity. It interrupts or prevents the pathophysiological process of lipid peroxidation responsible for the destruction of cell membranes. Silymarin acts not only as an antioxidant – reducing the generation of free radicals – but also as a means of stimulating the regeneration of the glutathione system, one of the most important protective systems of the liver.

Regenerative. Membranostabilizing. Silymarin stimulates the synthesis of proteins and phospholipids. Cell membranes are stabilized. Proprietary proteins and phospholipids restore the damaged structures of the hepatocyte. Restorative capacity is improved and regeneration of liver cells is accelerated. No such effect is noted in undamaged cells.

Hypocholesterolemic. Silymarin normalizes hyperlipidemia, reduces plasma levels of cholesterol and low-density lipoproteins (LDL).

Antifibrotic. Silymarin inhibits collagenase and elastase in the liver, helping to reduce the degree of fibrosis.

Anti-inflammatory. A key feature of silymarin/silibinin is the ability to block the 5-lipoxygenase pathway and have an inhibitory effect on leukotriene formation.

Pharmacokinetics

The main component of silymarin is silybinin. When taken orally, silybinin quickly dissolves and enters the intestine, then through the portal vein system 85% of it enters the liver and is selectively distributed in hepatocytes, where it is metabolized by conjugation. Up to 80% of the active substance during the first passage through the liver is excreted with bile in combination with glucuronides and sulfates. Due to deconjugation in the intestine, up to 40% of silybinin excreted with bile is reabsorbed and enters enter enterohepatic circulation, excretion period is 6.3 h. The bioavailability of the drug Legalon® 140 is 85%.

When taking milk thistle fruit extract at therapeutic doses (140 mg silymarin 3 times daily), the level of silybinin in bile is the same after repeated doses and after taking a single dose. The results showed that silybinin does not cumulate in the body.

After repeated oral doses of silymarin at 140 mg 3 times a day, a stable level of excretion with bile is achieved.

Indications

Active ingredient

Composition

One capsule contains:

The active ingredient:

The milk thistle fruit extract dry (36-44:1) – 173.0-186.7 mg, equivalent to 140 mg silymarin (DNFG), equivalent to 108.2 mg silymarin (HPLC/Herm.F.) per silybinin.

Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate.

The hard gelatin capsule shell, size “1”, which includes: gelatin, iron oxide red dye (E172), titanium dioxide (E171), sodium lauryl sulfate, iron oxide black dye (E172).

How to take, the dosage

Orally, after meals, with plenty of liquid.

1 capsule 3 times a day. The maintenance dose is 1 capsule 2 times a day.

The duration of therapy is determined by the doctor.

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

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