Leflaide20 mg, 30 pcs.

A drug with antiproliferative, immunomodulatory (immunosuppressive) and anti-inflammatory effects. The active metabolite of leflunomide A771726 inhibits the enzyme dehydrorotate dehydrogenase and has an antiproliferative effect. In vitro A771726 inhibits mitogen-induced proliferation and DNA synthesis of T-lymphocytes.

Indications

• Basic therapy of rheumatoid arthritis to reduce symptoms of the disease and delay the development of structural damage to the joints.
• Active form of psoriatic arthritis.

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Active ingredient

Leflunomide

Composition

How to take, the dosage

The initial dose is 100 mg daily for 3 days. The maintenance dose is 10-20 mg once daily.

Interaction

Increased adverse reactions may occur in the case of recent or concomitant use of hepatotoxic or hematotoxic drugs, or when these drugs are started after treatment with leflunomide without a “washout” procedure.

Special Instructions

Application is possible only after a thorough medical examination of the patient.

Contraindications

Liver function abnormalities, severe immunodeficiency states (including AIDS); expressed disorders of medullary hematopoiesis or anemia, leukopenia, thrombocytopenia due to other causes (except rheumatoid arthritis), severe infections, moderate or severe renal failure (due to little experience in clinical observation), severe hypoproteinemia (including nephrotic syndrome).including in nephrotic syndrome), pregnancy, lactation, childhood and adolescence under 18 years of age, hypersensitivity to leflunomide.

Side effects

Cardiovascular system: often – increase in BP.