Laticort, ointment 0.1% 15 g
€4.35 €3.87
Laticort is a synthetic nonhalogenated GCS for external use. It has a rapid anti-inflammatory, anti-edematous, antipruritic and anti-allergic effect. Due to local vasoconstrictor action it reduces exudative reactions.
The use of the drug Laticort in the recommended doses does not cause suppression of the hypothalamic-pituitary-adrenal system.
Pharmacokinetics
Absorption
After application of Laticort, the active substance accumulates in the epidermis, mainly in the granular layer.
Metabolism
Hydrocortisone butyrate absorbed through the skin is metabolized to hydrocortisone and other metabolites directly in the epidermis and subsequently, in the liver.
Elimation
Metabolites and a small portion of unchanged hydrocortisone butyrate are excreted by the kidneys and in the bile.
Indications
Uninfected, sensitive to glucocorticoids, skin diseases: dermatitis (including allergic, atopic, seborrheic), eczema (including contact, chronic, childhood), psoriasis (including scalp), erythroderma, photodermatoses.
Pharmacological effect
Pharmacological action
glucocorticoid, local anti-inflammatory, antiallergic, antiexudative, antipruritic.
Pharmacodynamics
Glucocorticosteroid for external use. It has anti-inflammatory, antiallergic, antipruritic, antiexudative effects, reduces capillary permeability. Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of PG and leukotrienes. Inhibits the migration of leukocytes and lymphocytes to the site of inflammation, inhibits the proteolytic activity of tissue kinins, retards the growth of fibroblasts, and prevents the development of connective tissue in the site of inflammation. Reduces the manifestations of hypersensitivity reactions, proliferative and exudative processes occurring in the connective tissue at the site of inflammation, reduces hyperemia.
Pharmacokinetics
Absorption: After application to the skin, hydrocortisone easily reaches the stratum corneum of the skin. It is slightly adsorbed into the systemic circulation and may have a systemic effect. The absorption of hydrocortisone is increased when used over large areas of skin, when applied to the face or skin folds, and when used as an occlusive dressing for a long time. The absorption of hydrocortisone from the epidermis in children is more pronounced than in adults. Can accumulate in cells of the stratum corneum of the skin.
Metabolism: biotransformed directly in the epidermis, and the absorbed part in the liver. Metabolic products – butyric acid and hydrocortisone are quickly eliminated from the body. Due to the absence of halogens in the formula and the peculiarities of kinetics, the risk of local and systemic side effects is significantly reduced.
Special instructions
Avoid long-term use of the drug (with prolonged use on a large surface, symptoms of hypercortisolism may appear).
If an infection develops at the application site, antibacterial treatment must be prescribed.
Particular caution should be applied to the skin of the face (possible side effects – telangiectasia, atrophy, dermatitis perioralis, even after short-term use), in case of existing atrophic skin conditions (especially in elderly people).
Do not vaccinate during drug therapy.
The drug does not limit psychophysical ability, the ability to drive vehicles and operate machinery in motion.
Active ingredient
Hydrocortisone
Composition
in tubes of 15 g; 1 tube in a cardboard pack.
1 g:
Pregnancy
Glucocorticoids cross the placenta. The effect on the fetus can be especially pronounced when the drug is applied to large surfaces. Laticort can be used in pregnant women only in cases where the benefit outweighs the risk of use. Do not use in the first trimester of pregnancy.
During breastfeeding – with extreme caution (short term, on a small surface). Do not apply to breast skin.
Contraindications
Hypersensitivity, bacterial skin infections, mycoses, acne vulgaris and rosacea, perioral dermatitis (dermatitis perioralis), period after vaccination, age up to 2 years.
Not recommended for use during pregnancy, unless the therapeutic benefit to the mother outweighs the risk to the fetus.
Side Effects
Rare: possible skin irritation, systemic glucocorticoid effects (with long-term use, when applied under occlusive dressings and/or on large areas of damaged skin).
Interaction
There are no data on drug interactions between Laticort® and other drugs.
Overdose
May appear after prolonged use on large areas of the skin in the form of symptoms of hypercortisolism. Symptoms disappear after stopping treatment.
Specifications
The ointment is an almost colorless, translucent fatty mass.
Storage conditions
At a temperature not exceeding 25 °C.
Keep out of the reach of children.
Shelf life
3 years.
Do not use after the expiration date indicated on the package.
Manufacturer
Pharmaceutical plant Elfa A.O., Poland
Manufacturer | Jelfa Pharmzavod, Poland |
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Medication form | topical ointment |
Brand | Jelfa Pharmzavod |
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