Lastet, 50 mg capsules, 20 pcs.

An antitumor agent. It is a semi-synthetic derivative of podophyllotoxin. Mechanism of action is associated with inhibition of topoisomerase II. Inhibits mitosis, blocks cells in S-G₂-interphase of cell cycle, in higher doses acts in G₂-phase. Cytotoxic effects against normal healthy cells are observed only when etoposide is used in high doses.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

In concomitant use with other drugs causing myelodepression, additive suppression of bone marrow function is possible.

Concomitant use with cisplatin may decrease etoposide clearance and increase its toxicity.

Cyclosporine in high doses may decrease etoposide clearance and increase its duration of action, and leukopenia may increase.

Special Instructions

With caution, use in patients with previous radiation or chemotherapy, with chicken pox, herpes zoster, infectious mucous membrane lesions, cardiac rhythm disorders, increased risk of myocardial infarction, liver function disorders, nervous system disorders (epilepsy), chronic alcoholism, children over 2 years old.

In case of impaired renal function, the dose is reduced in accordance with the CK values.

Peripheral blood count should be monitored before and during therapy.

Patients and family members should not be vaccinated.

Itoposide has been found in experimental studies to have mutagenic effects.

Impact on the ability to drive and operate machinery

At the time of treatment, one should refrain from activities requiring increased attention and quick psychomotor reactions.

Contraindications

Side effects

Blood system disorders: leukopenia, anemia; rarely – thrombocytopenia.

In the digestive system: nausea, vomiting; rarely – anorexia, mucositis, diarrhea; when used in high doses – toxic liver reactions.

CNS and peripheral nervous system disorders: drowsiness, increased fatigue; peripheral nervous system disorders.

Metabolic disorders: hyperuricemia; metabolic acidosis in high doses.

Cardiovascular system: tachycardia, arterial hypotension.

Reproductive system disorders: azoospermia, amenorrhea.

Allergic reactions: chills, fever, bronchospasm.

Dermatological reactions: alopecia.