An antitumor agent. It is a semi-synthetic derivative of podophyllotoxin. Mechanism of action is associated with inhibition of topoisomerase II. Inhibits mitosis, blocks cells in S-G2-interphase of cell cycle, in higher doses acts in G2-phase. Cytotoxic effects against normal healthy cells are observed only when etoposide is used in high doses.
Germ cell tumors (testicular tumors, choriocarcinoma), ovarian cancer, small and non-small cell lung cancer, lymphogranulematosis, non-Hodgkin lymphoma, gastric cancer (for monotherapy and as part of combination therapy), Ewing’s sarcoma, Kaposi’s sarcoma, neuroblastoma, breast cancer (with metastases to liver, pleura), acute non-lymphoblastic leukemia, mesothelioma.
1 capsule – etoposide 50 mg
How to take, the dosage
It is established individually, depending on the indications and stage of the disease, the state of the hematopoiesis system, the scheme of anti-tumor therapy.
In concomitant use with other drugs causing myelodepression, additive suppression of bone marrow function is possible.
Concomitant use with cisplatin may decrease etoposide clearance and increase its toxicity.
Cyclosporine in high doses may decrease etoposide clearance and increase its duration of action, and leukopenia may increase.
With caution, use in patients with previous radiation or chemotherapy, with chicken pox, herpes zoster, infectious mucous membrane lesions, cardiac rhythm disorders, increased risk of myocardial infarction, liver function disorders, nervous system disorders (epilepsy), chronic alcoholism, children over 2 years old.
In case of impaired renal function, the dose is reduced in accordance with the CK values.
Peripheral blood count should be monitored before and during therapy.
Patients and family members should not be vaccinated.
Itoposide has been found in experimental studies to have mutagenic effects.
Impact on the ability to drive and operate machinery
At the time of treatment, one should refrain from activities requiring increased attention and quick psychomotor reactions.
Severe myelodepression, marked liver and renal dysfunction, pregnancy, children under 2 years of age, hypersensitivity to podophyllin or its derivatives.
Blood system disorders: leukopenia, anemia; rarely – thrombocytopenia.
In the digestive system: nausea, vomiting; rarely – anorexia, mucositis, diarrhea; when used in high doses – toxic liver reactions.
CNS and peripheral nervous system disorders: drowsiness, increased fatigue; peripheral nervous system disorders.
Metabolic disorders: hyperuricemia; metabolic acidosis in high doses.
Cardiovascular system: tachycardia, arterial hypotension.
Reproductive system disorders: azoospermia, amenorrhea.
Allergic reactions: chills, fever, bronchospasm.
Dermatological reactions: alopecia.
Nippon Kaiaku, Japan
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