Larigama, 2 ml 10 pcs

A combined multivitamin remedy. The action of the combination is determined by the properties of the vitamins in its composition. Neurotropic B vitamins have beneficial effects in inflammatory and degenerative diseases of the nervous system and musculoskeletal system.

Thiamine (vitamin B₁) is involved in the conduction of the nerve impulse.

Pyridoxine (vitamin B₆) has a vital effect on the metabolism of proteins, carbohydrates and fats, is necessary for normal hematopoiesis and the functioning of the central and peripheral nervous system. It provides synaptic transmission, the processes of inhibition in the CNS, participates in the transport of sphingosine, which is part of the nerve sheath, participates in the synthesis of catecholamines.

The cyanocobalamin (vitamin B₁₂) is involved in the synthesis of nucleotides, is an important factor in normal growth, hematopoiesis and development of epithelial cells, is necessary for the metabolism of folic acid and the synthesis of myelin.

Lidocaine has an anesthetic effect at the injection site, dilates blood vessels and promotes the absorption of vitamins. The local anesthetic effect of lidocaine is due to the blockade of potential-dependent Na⁺-channels, which prevents the generation of impulses in the endings of sensitive nerves and conduct of pain impulses along the nerve fibers.

Indications

Myalgia (muscle pain), Osteochondrosis, Pain, Lumbago, Neuralgia, Neuritis, Sciatica In the complex therapy of the following neurological diseases: trigeminal neuralgia; facial nerve neuritis; pain syndrome caused by spinal diseases (intercostal neuralgia, lumboishyalgia, lumbar syndrome, cervical syndrome, cervical shoulder syndrome, radicular syndrome caused by degenerative changes in the spine); polyneuropathy of various etiology (diabetic, alcoholic).

Composition

Intravenous solution from pinkish-red to red in color, with a peculiar odor.

Associates:

benzyl alcohol – 20 mg,

sodium tripolyphosphate – 10 mg,

potassium hexacyanoferrate – 0.1 mg,

sodium hydroxide solution 10 M- to pH 4.0-5.0,

d/i water – up to 1 ml.

Interaction

Vitamin B₁ completely disintegrates in solutions containing sulfites, is incompatible with oxidizing and reducing agents (mercury chloride, iodide, carbonate, acetate, tannic acid, iron(III)-ammonium citrate), as well as sodium phenobarbital, riboflavin, benzylpenicillin, dextrose and sodium metabisulfite.

Levodopa reduces the effect of therapeutic doses of vitamin B₆.

Vitamin B₁₂ is incompatible with heavy metal salts, ascorbic acid.

Directions for use

In case of pronounced pain syndrome, it is reasonable to start treatment with intravenous injection (deep) of 2 ml daily for 5-10 days with further transition either to oral administration of this combination in fixed doses, or to more rare injections (2-3 times a week for 2-3 weeks) with possible continuation of therapy by oral dosage form.

Special Instructions

In case of accidental intravenous injection, the patient should be under medical supervision or hospitalized depending on the severity of symptoms.

In case of overdose, dizziness, nausea, vomiting, pruritus, urticaria, increased sweating, tachycardia may occur.

Contraindications

Severe and acute decompensated heart failure; pregnancy; lactation (breast-feeding) period; childhood (due to lack of data); hypersensitivity to the components of the combined agent.

With caution

Heart rhythm disorders, severe arterial hypotension.