Larigama, 2 ml 10 pcs

A combined multivitamin remedy. The action of the combination is determined by the properties of the vitamins in its composition. Neurotropic B vitamins have beneficial effects in inflammatory and degenerative diseases of the nervous system and musculoskeletal system.

Thiamine (vitamin B₁) is involved in the conduction of the nerve impulse.

Pyridoxine (vitamin B₆) has a vital effect on the metabolism of proteins, carbohydrates and fats, is necessary for normal hematopoiesis and the functioning of the central and peripheral nervous system. It provides synaptic transmission, the processes of inhibition in the CNS, participates in the transport of sphingosine, which is part of the nerve sheath, participates in the synthesis of catecholamines.

The cyanocobalamin (vitamin B₁₂) is involved in the synthesis of nucleotides, is an important factor in normal growth, hematopoiesis and development of epithelial cells, is necessary for the metabolism of folic acid and the synthesis of myelin.

Lidocaine has an anesthetic effect at the injection site, dilates blood vessels and promotes the absorption of vitamins. The local anesthetic effect of lidocaine is due to the blockade of potential-dependent Na⁺-channels, which prevents the generation of impulses in the endings of sensitive nerves and conduct of pain impulses along the nerve fibers.

Functional features

After intramuscular administration, thiamine is quickly absorbed and enters the blood. The concentration of thiamine is 484 ng/ml 15 minutes after administration of the drug at a dose of 50 mg (on the 1st day of administration). Thiamine is unevenly distributed in the body. The thiamine content in leukocytes is 15%, in erythrocytes – 75% and in plasma – 10%. Due to the lack of significant reserves of the vitamin in the body, it must be ingested daily. Thiamine crosses the blood-brain barrier and placental barrier and is found in breast milk. The main metabolites of thiamine are thiaminecarboxylic acid, pyramine and some unknown metabolites. Of all the vitamins, thiamine is stored in the body in the smallest quantities. The adult human body contains about 30 mg of thiamine in the form of 80% thiamine pyrophosphate, 10% thiamine triphosphate and the rest in the form of thiamine monophosphate. Thiamine is excreted in the urine, T1/2 α-phase – 0.15 hours, β-phase – 1 hour and terminal phase – within 2 days.

After intramuscular administration, pyridoxine is quickly absorbed into the systemic circulation and distributed in the body, acting as a coenzyme after phosphorylation of the CH2OH group in the 5th position. Pyridoxine is distributed throughout the body, penetrates the placental barrier and is found in breast milk. The body contains 40-150 mg of vitamin B6, its daily elimination rate is about 1.7-3.6 mg with a replacement rate of 2.2-2.4%. About 80% of pyridoxine is bound to plasma proteins. Pyridoxine is deposited in the liver and oxidized to 4-pyridoxine acid, which is excreted in the urine, a maximum of 2-5 hours after absorption.

After parenteral administration, cyanocobalamin forms complexes with the transport protein transcobalamin, which are quickly absorbed by the liver, bone marrow and other organs. Cyanocobalamin is excreted into bile and takes part in the enterohepatic circulation. Penetrates through the placental barrier.

After intramuscular administration of lidocaine, absorption is almost complete. Distribution is rapid, Vd is about 1 l/kg (lower in patients with heart failure). Protein binding depends on the concentration of the active substance in plasma and is 60-80%. Metabolized mainly in the liver with the formation of active metabolites, which can contribute to the manifestation of therapeutic and toxic effects, especially after infusion for 24 hours or more. T1/2 tends to be biphasic with a distribution phase of 7-9 minutes. In general, T1/2 depends on the dose, is 1-2 hours and can increase to 3 hours or more during long-term IV infusions (more than 24 hours). Excreted by the kidneys in the form of metabolites, 10% unchanged.