Laifevit, capsules 200 mg 30 pcs

Pharmacological action – replenishing vitamin E deficiency.

Pharmacodynamics

Biologically active tocopherols protect cellular respiration intermediates from oxidation of the functional groups of their molecules. Active tocopherols are able to oxidize into semiquinones, which are reduced back to tocopherols in the body.

If sufficient tocopherols are present in the body, they protect unstable mediators and metabolites of cellular respiration from oxidation.

In redox processes at the level of cellular metabolism under pathological conditions, they play a buffering role.

Vitamin E (α-tocopherol), the most effective of the tocopherols, in the human body acts as a cellular antioxidant and a substance that binds free oxygen radicals.

Pharmacokinetics

Absorption from the duodenum (the presence of bile acids salts, fats, normal functioning of the pancreas is necessary) is 20-40%. With increasing dose the degree of absorption decreases. Tmax – 4 hours. It is deposited in all organs and tissues, especially in adipose tissue.

It penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the blood of the mother penetrates into the fetus. It penetrates into breast milk.

Excretion mainly through the gastrointestinal tract, with bile – more than 90%, less than 6% is excreted by the kidneys as glucuronides and other metabolites.