Lafrax, eye and ear drops 0.3% 5 ml

Antimicrobial agent of broad spectrum of the group of fluoroquinolones, acts on the bacterial enzyme DNA-gyrase, which provides superspiralization and thus the stability of DNA-bacteria (destabilization of DNA chains leads to their death). It has a bactericidal effect. It is active against microorganisms producing beta-lactamases and rapidly growing atypical mycobacteria.

Sensitive: Staphylococcus aureus (including strains), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Corynebacterium spp, Micrococcus spp., Bacillus spp., Enterobacteriaceae (Escherichia coli, Citrobacter, Enterobacter spp., Klebsiela spp., Proteus spp, Salmonella spp., Serratia spp., Shigella spp.), Pseudomonas aeruginosa and Pseudomonas species, Haemophilus influenza, Haemophilus ducreyi, Branhamella catarhalis, Neisseria gonorrhoeae, Neisseria menengitidis, Acinetobacter spp,

The drug is also active against Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae and some other mycoplasmas. Clostridium species, Bacteroides species and Peptococcus species are resistant. Resistance of Pseudomonas aeruginosa varies between 15-20% and resistance of Staphylococcus aureus between 5-10%.

Pharmokinetics

Four hours after topical application the average concentration of Ofloxacin in lacrimal fluid exceeds 2 mkg/ml (minimum concentration required for suppression of growth in vitro by 90% for the most common strains of pathogens of infectious eye diseases – MIC90). In the case of intact tympanic membranes, dripping of Ofloxacin into the ear is accompanied by minimal absorption in the middle ear. However, uptake ofloxacin is enhanced with tympanic membrane perforations.

After injection of 0.3% ofloxacin solution in adults with tympanic membrane perforation, the maximum concentration in serum is 10 ng/ml. Maximum serum concentration of ofloxacin after 10 days of regular topical administration is 1000 times lower than when using standard oral doses of ofloxacin.

Indications

Active ingredient

Composition

How to take, the dosage

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