Klindovit, gel 1% 30 g

This antibiotic from the lincosamide group affects all strains of Propionibacterium acnes. Once applied to the surface of the skin, the product rapidly penetrates into the upper layers and accumulates in comedones, exhibiting significant antibacterial activity.

The average concentration of antibiotic in comedones exceeds the minimum level of suppression of Propionibacterium acnes strains, which are the causative agents of acne. From the time of application of the gel on the skin surfaces, rather low concentrations of clindamycin are determined in the composition of blood plasma and urine.

Indications

Acne.

Pharmacological effect

This antibiotic from the lincosamide group affects all strains of Propionibacterium acnes. After application to the surface of the skin, the product quickly penetrates the upper layers, accumulates in comedones, exhibiting significant antibacterial activity.

At the same time, the average concentration of the antibiotic in the composition of comedones exceeds the minimum indicator for suppressing Propionibacterium acnes strains, which are the causative agents of acne. From the moment the gel is applied to the skin surfaces, a rather low concentration of clindamycin is determined in the blood plasma and urine.

Special instructions

When using, avoid contact of the drug with the eyes and mouth, and after applying the gel, wash your hands.

Active ingredient

Clindamycin

Composition

1 g of gel for external use contains:

Clindamycin (phosphate form) 10 mg.

Excipients:

Methyl parahydroxybenzoate (nipagin),

allantoin,

tocopherol phosphate disodium lauryl iminodipropionate,

propylene glycol,

macrogol 400 (polyethylene oxide 400),

carbomer (copolymer, interpolymer),

sodium hydroxide,

purified water.

Pregnancy

Clindovit can be used externally during pregnancy if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

If it is necessary to use it during lactation, it is recommended to stop breastfeeding.

Contraindications

– Crohn’s disease.

– Pseudomembranous colitis (including history).

– Ulcerative colitis (including history).

– Hypersensitivity to clindamycin or lincomycin.

With caution:

– In patients under 12 years of age (data on safety and effectiveness are not available).

– During lactation (breastfeeding).

– In patients predisposed to the development of allergic reactions.

– When taking muscle relaxants simultaneously.

Side Effects

The drug is usually well tolerated.

– Local reactions: Possible irritation (at the site of application), burning, itching, dry skin, erythema, peeling, increased sebum secretion, contact dermatitis.

– Systemic reactions: Pseudomembranous enterocolitis (probability of development occurs with systemic absorption of clindamycin).

Interaction

Clindamycin and erythromycin are antagonists, so simultaneous administration of these antibiotics is not recommended. There is cross-resistance between clindamycin and lincomycin.

Clindamycin may enhance the effect of muscle relaxants by interfering with neuromuscular transmission.

Storage conditions

At a temperature of 15–25 °C.

Shelf life

2 years.

Manufacturer

Akrikhin JSC, Russia