Klenzit, gel 0.1% 15 g

The active ingredient of the drug is a retinoid derivative – Adapalene, which has anti-inflammatory and comedolytic activity. Adapalene participates in normalization of epidermal differentiation and keratinization processes, inhibits formation of microcomedones and reduces manifestations of inflammation.

The mechanism of action of the active ingredient of Klenzit lies in its ability to influence specific gamma-receptors of the epidermal cells of the skin, reducing their adhesive surface in the mouths of oil-hair follicles.

In vivo and in vitro studies have proven that Adapalen has a pronounced anti-inflammatory effect due to its effect on inflammatory factors. It inhibits the metabolism of arachidonic acid and migration of leukocytes.

When the gel is applied externally, the systemic absorption of its active ingredient Adapalen is quite low, about 4% of the used dose.

From the systemic bloodstream, it is excreted by the liver.

Indications

Acne.

Pharmacological effect

The active substance of the drug is a retinoid derivative – Adapalene, which exhibits anti-inflammatory and comedolytic activity. Adapalene takes part in the normalization of the processes of epidermal differentiation and keratinization, inhibits the formation of microcomedones and reduces the manifestations of the inflammatory process.

The mechanism of action of the active substance of the drug Klenzit lies in its ability to influence specific gamma receptors of epidermal cells of the skin, reducing their adhesive surface at the mouths of the pilosebaceous follicles.

In vivo and in vitro studies have proven that Adapalene has a pronounced anti-inflammatory effect due to its influence on the factors of the inflammatory process. Inhibits the metabolism of arachidonic acid and the migration of leukocytes.

When the gel is applied externally, the systemic absorption of its active substance Adapalene is quite low, about 4% of the dose used.

From the systemic circulation, excreted by the liver.

Special instructions

Avoid getting the gel in your eyes and lips.

In case of accidental contact of the drug with the mucous membranes of the eyes, mouth or nose, rinse them thoroughly with warm water.

Avoid direct sunlight, as… Skin irritation may occur. Treatment can be continued if sun exposure is kept to a minimum (use of sunglasses and hats).

The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfumes or alcohol-containing products) is not recommended.

Adapalene applied to the skin in the evening can be combined with acne medications used in the morning.

Active ingredient

Adapalene

Composition

1 gram of gel contains:

Active substance:

Adapalene 1 mg.

Excipients:

Disodium edetate;

Carbomer 940 (Carbopol 940);

Propylene glycol;

Methyl parahydroxybenzoate;

Phenoxyethanol;

Poloxamer 407;

Sodium hydroxide;

Purified water.

Pregnancy

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Contraindications

Hypersensitivity to the components of the drug;
Pregnancy;
Lactation period (breastfeeding).

The drug should be used with caution for dermatitis and eczema.

Side Effects

Dermatological reactions:

skin irritation (treatment should be suspended until the skin irritation disappears or the frequency of use should be reduced).

Interaction

Since adapalene does not interact with oxygen and is not destroyed by light, simultaneous treatment of acne with drugs such as clindamycin phosphate or benzoyl peroxide is possible.

Overdose

An overdose of the drug is unlikely.

Storage conditions

In a place protected from light, at temperatures below 25 °C

Shelf life

3 years.

Manufacturer

Glenmark Pharmaceuticals Ltd, India