Kipferon, vaginal and rectal suppositories 200 mg+500000 me 10 pcs

Kipferon is a complex drug form containing human recombinant interferon-α2 and a complex immunoglobulin preparation (CIP). Interferon-α2 is an activator of innate and acquired immunity; it has expressed antiviral activity, strengthens protection against viral, chlamydial, mycoplasma and bacterial infections, has an immunomodulatory effect in development of immunological reactions, promotes growth and maintenance of normal intestinal and vaginal flora.

The biological activity of interferon-α2 is realized through its interaction with the receptor apparatus of immunocompetent and other cells, resulting in increased expression of HLA I and HLA II molecules on all cell types and regulation of cell cooperation, increased activity of natural killer cells and in resistance of intact cells against their cytolytic action, proliferation of CD8 T-cells. Increases the production of gamma-interferon by natural killer cells. Complex immunoglobulin preparation KIP contains specific and non-specific immunoglobulins of classes G, M, A.

The combination of antiviral, antichlamydial, antibacterial and antitoxic antibodies belonging to different immunoglobulin classes provides agglutination, neutralization and precipitation of etiotropic pathogenic agents. In the place of application it provides stabilization of interferon from mucous membrane secretions, normalizes local immunity due to inflow of IgA and IgM with suppositories (substitution effect), increases activity of locally produced cytokines.

Indications

The drug is used in the complex treatment of diseases accompanied by secondary immunodeficiency states:

acute respiratory diseases, inflammatory diseases of the oropharynx of bacterial and viral etiology in children and adults;
acute viral (rotavirus) and bacterial (salmonellosis, dysentery, coli infection) intestinal infections, including manifestations of intestinal dysbiosis of varying severity in children;
urogenital chlamydia in women (including pregnant women in the II-III trimesters of pregnancy), including manifestations of vaginal dysbiosis, vulvovaginitis, uterine cervicitis, cervical erosion.

Pharmacological effect

Kipferon is a complex dosage form containing human recombinant interferon-α2 and a complex immunoglobulin preparation (CIP). Interferon-α2 is an activator of innate and acquired immunity, has pronounced antiviral activity, enhances protection against viral, chlamydial, mycoplasma and bacterial infections, has an immunomodulatory effect in the development of immunological reactions, promotes the growth and preservation of intestinal and vaginal flora.

The biological activity of interferon-α2 is realized through interaction with the receptor apparatus of immunocompetent and other cells, leading to increased expression of HLA I and HLA II molecules on the surface of all types of cells and regulation of cell cooperation, increased activity of natural killer cells, as well as imparting resistance to intact cells against their cytolytic action and proliferation of CD8 T cells. Increases the production of interferon gamma by natural killer cells. The complex immunoglobulin preparation KIP contains specific and nonspecific immunoglobulins of classes G, M, A.

The combination of antiviral, antichlamydial, antibacterial and antitoxic antibodies belonging to various classes of immunoglobulins ensures agglutination, neutralization and precipitation of etiotropic pathogenic agents. At the site of application, it ensures stabilization of interferon from the secretions of the mucous membranes, normalizes local immunity due to the supply of IgA and IgM with suppositories (replacement effect), and increases the activity of locally produced cytokines.

Special instructions

When used in recommended doses, the drug does not affect the behavior or functional parameters of the body, and also does not affect the ability to drive vehicles or machinery.

Active ingredient

Normal human immunoglobulin [IgG, IgM, IgA], Interferon alpha-2b

Composition

Active ingredients:

immunoglobulin complex preparation (ICP) – 0.2 g,

interferon alpha-2b human,

recombinant – 500,000 IU;

Excipients:

special purpose fat “SolPro” for confectionery,

for chocolate products and candies – 0.838 g,

petroleum paraffin solid P-2 – 0.085 g,

emulsifier “Solid” (T-2) – 0.085 g,

sodium hydrogen phosphate dodecahydrate – 0.055 mg,

sodium dihydrogen phosphate dihydrate – 0.018 mg,

sodium chloride – 0.110 mg,

purified water – 0.012 g

Contraindications

Individual intolerance to individual components, pregnancy first trimester, lactation period.

Storage conditions

In a dry place, protected from light, at a temperature of 2–8 °C.

Shelf life

1 year

Manufacturer

Binnopharm, Russia