Ketorol, 10 mg 20 pcs.

Pharmacodynamics

Non-steroidal anti-inflammatory drug (NSAID), has a pronounced analgesic effect, anti-inflammatory and moderate antipyretic effect.

The mechanism of action is related to non-selective inhibition of cyclooxygenase (COX) activity – COX-1 and COX-2, catalyzing formation of prostaglandins from arachidonic acid, which play an important role in the pathogenesis of pain, inflammation and fever.

Ketorolac is a racemic mixture of [-]S and [+]R enantiomers, with analgesic effect due to the [-]S form. By the analgesic effect the drug is comparable with morphine and is much superior to other NSAIDs.

The drug does not affect the opioid receptors, does not inhibit respiration, does not cause drug addiction, has no sedative and anxiolytic effects.

After oral administration the development of analgesic effect is noted in 1 hour.

Pharmacokinetics

When taken orally ketorolac is well and quickly absorbed in the gastrointestinal tract (GIT). The bioavailability of ketorolac is 80-100%, maximum concentration (Cmax) after oral administration of 10 mg is 0.82-1.46 mcg/ml, time to reach maximum concentration (TCmax) is 10-78 min. Fat-rich food decreases the maximum blood concentration of the drug and delays its attainment by one hour. The time of reaching the equilibrium concentration (Css) of the drug in per oral administration of 10 mg 4 times per day is 24 hours and the concentration is 0.39-0.79 mcg/ml. The volume of distribution is 0.15-0.33 l/kg. In patients with renal insufficiency the distribution volume of the drug may increase by 2 times, and the distribution volume of its R-enantiomer – by 20%.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Overdose

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