Ketoprofen-ACOS, gel 5% 30 g

Pharmacotherapeutic group: Non-steroidal anti-inflammatory drug (NSAIDs)

ATC code: M02AA10

Pharmacodynamics:

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) has local anti-inflammatory analgesic and antipyretic effects associated with inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) activity regulating prostaglandin (Pg) synthesis. In joint syndrome, it causes less arthralgia at rest and less “morning stiffness” and swollen joints when moving. Ketoprofen has no catabolic effect on articular cartilage.

Pharmacokinetics:

When used externally it is absorbed extremely slowly and almost does not cumulate in the body. The bioavailability of ketoprofen is about 5%. After external use in a dose of 50-150 mg, the plasma concentration after 5-8 hours is 008-015 mcg/ml.

Indications

– Acute and chronic inflammatory diseases of the musculoskeletal system (articular syndrome with exacerbation of gout, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, osteoarthritis, osteochondrosis with radicular syndrome, radiculitis, inflammatory damage to ligaments and tendons, bursitis, sciatica, lumbago);

– muscle pain of rheumatic and non-rheumatic origin;

– post-traumatic inflammation of soft tissues and the musculoskeletal system (damage and ruptures of ligaments, bruises).

The drug is intended for symptomatic therapy to reduce pain and inflammation at the time of use and does not affect the progression of the disease.

Pharmacological effect

Pharmacotherapeutic group: non-steroidal anti-inflammatory drug (NSAID)

ATX code: M02AA10

Pharmacodynamics:

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has local anti-inflammatory analgesic and antipyretic effects associated with the suppression of the activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which regulate the synthesis of prostaglandins (Pg). In case of articular syndrome, it causes a weakening of arthralgia at rest and during movement, a decrease in “morning stiffness” and swelling of the joints. Ketoprofen does not have a catabolic effect on articular cartilage.

Pharmacokinetics:

When applied externally, it is absorbed extremely slowly and practically does not accumulate in the body. The bioavailability of ketoprofen is about 5%. After external use at a dose of 50-150 mg, the plasma concentration after 5-8 hours is 008-015 mcg/ml.

Special instructions

The drug should be applied only to intact areas of the skin, avoiding contact with open wounds, eyes and mucous membranes.

After applying the drug, you must wash your hands.

Do not use with occlusive dressings.

Before using the gel, patients with impaired liver and/or kidney function, gastrointestinal diseases, a history of bronchial asthma, chronic heart failure should consult a doctor.

Active ingredient

Ketoprofen

Composition

100 g of gel contain:

active substance: ketoprofen 5.0 g;

excipients: carbomer (carbopol) 1.5 g; ethanol (ethyl alcohol) 96% 32.0 g; trolamine (triethanolamine) 6.7 g; lavender oil 0.1 g; purified water up to 100 g.

Pregnancy

The use of the drug in the third trimester of pregnancy is contraindicated.

The use of the drug in the first and second trimester is possible only after consultation with a doctor if the expected benefit to the mother outweighs the potential risk to the fetus.

Use during lactation is not recommended.

Contraindications

Hypersensitivity to ketoprofen or other non-steroidal anti-inflammatory drugs, complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history of) damage to the skin (weeping dermatoses, eczema, infected abrasions of the wound) at the site of intended application, pregnancy, third trimester and lactation period – children’s age (up to 6 years).

With caution:

Erosive and ulcerative lesions of the gastrointestinal tract, severe renal and liver dysfunction, chronic heart failure, bronchial asthma, pregnancy I-II trimester, hepatic porphyria, elderly age, children from 6 to 12 years.

Side Effects

Local reactions: allergic dermatitis eczema skin hyperemia photodermatitis bullous dermatitis exanthema purpura.

Systemic reactions: urticaria, generalized skin rash, swelling, photosensitivity.

Overdose

The extremely low systemic absorption of the active components of the drug when applied externally makes overdose almost impossible.

Storage conditions

In a place protected from light at a temperature not exceeding 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after expiration date.

Manufacturer

Sintez, Russia