Ketonal, 50 mg capsules 25 pcs

Pharmgroup:

NSAIDs.
Pharmic action:

Ketonal is an NSAID, a propionic acid derivative.

It has analgesic, anti-inflammatory and antipyretic effects.

By inhibiting COX-1 and COX-2 and, in part, lipooxygenase, ketoprofen inhibits the synthesis of prostaglandins and bradykinin and stabilizes lysosomal membranes.

Ketoprofen has no negative effect on the state of articular cartilage.

Indications

Symptomatic therapy of painful and inflammatory processes of different genesis, including:

Inflammatory and degenerative diseases of the musculoskeletal system:

Active ingredient

Composition

1 capsule contains:

Active substance:

Ketoprofen – 50 mg.

Associates:

Lactose,

Magnesium stearate,

Silicon dioxide colloid.

Capsule shell composition:

gelatin, titanium dioxide, Patent blue V dye.

How to take, the dosage

Adults take 1-2 capsules 2-3 times a day; or 1 tablet forte 2-3 times a day; or 1 tablet retard 1-2 times a day.

The capsules and tablets should be taken with or immediately after a meal, without chewing, with plenty of water.

Interaction

Ketoprofen reduces the effect of diuretics, antihypertensive agents.

It enhances the effect of oral hypoglycemic drugs.

Accelerates the effect of some anticonvulsants (e.g., phenytoin).

Concomitant use with other NSAIDs, salicylates, GCS and ethanol increases the risk of gastrointestinal bleeding.

Concomitant use with anticoagulants, thrombolytics, antiaggregants increases the risk of bleeding.

The risk of renal dysfunction increases with concomitant use of diuretics or ACE inhibitors.

Concomitant use increases concentrations of cardiac glycosides, slow calcium channel blockers, lithium preparations, cyclosporine, methotrexate.

Ketoprofen may decrease the effectiveness of mifepristone. NSAIDs should not be started before 8-12 days after withdrawal of mifepristone.

Special Instructions

Ketonal may be washed with milk or taken with antacids in order to reduce the frequency of gastrointestinal disorders (milk and antacids do not affect absorption of ketoprofen).

When prolonged use of NSAIDs, the blood count and hepatic and renal function should be monitored, especially in elderly patients.

Caution should be exercised and BP should be monitored more frequently when using ketoprofen to treat patients with arterial hypertension, cardiovascular disease, which leads to fluid retention.

Like other NSAIDs, ketoprofen can mask the symptoms of infectious diseases.

Influence on driving and operating machinery

There are no data on adverse effects of Ketoprofen in recommended doses on the ability to drive or operate machinery. However, patients who have noted unusual effects while taking Ketonal® should be cautious when driving or operating machinery during potentially dangerous activities requiring increased concentration and rapid psychomotor reaction time.

Contraindications

Side effects

Prevalence of adverse reactions:

Digestive system disorders: widespread – dyspepsia (nausea, flatulence, diarrhea or constipation, vomiting, decreased or increased appetite), abdominal pain, stomatitis, dry mouth; non-spread (with long-term use in high doses – ulceration of the mucous membrane of the GIT, liver function disorders); rare – GIT perforation, worsening Crohn’s disease, melena, GIT bleeding, transient increase in liver enzymes.

CNS and peripheral nervous system disorders: common – headache, dizziness, drowsiness, fatigue, nervousness, nightmares; rare – migraine, peripheral neuropathy; very rare – hallucinations, disorientation, speech disorders.

Sensory organs: rare – tinnitus, change in taste, blurred vision, conjunctivitis.

Cardiovascular system disorders: rare – tachycardia, arterial hypertension, peripheral edema.

Hematopoietic system: decreased platelet aggregation; rare – anemia, thrombocytopenia, agranulocytosis, purpura.

Urinary system disorders: rare – renal dysfunction, interstitial nephritis, nephrotic syndrome, hematuria (with prolonged use of NSAIDs and diuretics).

Allergic reactions: common – itching, urticaria; non-spread – rhinitis, dyspnea, bronchospasm, angioedema, anaphylactoid reactions.

Others: rare – hemoptysis, metrorrhagia.

Overdose

Symptoms: nausea, vomiting, abdominal pain, vomiting blood, melena, impaired consciousness, respiratory depression, seizures, renal failure, renal failure.

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy is carried out.

Histamine H2-receptor blockers, proton pump inhibitors, prostaglandin inhibitors are indicated. There is no specific antidote.

Similarities