Kemeruvir, 600 mg 60 pcs

Clinical and Pharmacological Group

Antiviral drug active against HIV

Pharmacotherapeutic group

Antiviral [HIV] medicine

Indications

Treatment of HIV infection in adults and children over the age of 6 years and weighing 20 kg or more who have previously received antiretroviral therapy (in combination with low dose ritonavir and other antiretroviral drugs).

Pharmacological effect

Clinical and pharmacological group

Antiviral drug active against HIV

Pharmacotherapeutic group

Antiviral [HIV] agent

Active ingredient

Darunavir

Contraindications

* Hypersensitivity to darunavir or any components of the drug.

* Concomitant use with drugs that are metabolized primarily by the cytochrome P450 3A4 isoenzyme, and an increase in plasma concentrations is associated with serious and/or life-threatening side effects (narrow therapeutic range). These drugs include antihistamines (astemizole, terfenadine), alfuzosin, quetiapine, sildenafil (used to treat pulmonary arterial hypertension), rifampicin, sedatives/hypnotics (triazolam, oral midazolam), gastrointestinal motility stimulants (cisapride), drugs containing St. John’s wort extract, drugs containing ergot alkaloids (ergotamine, dihydroergotamine, ergometrine and methylergometrine), antiarrhythmic drugs (amiodarone, bepridil, quinidine, lidocaine for systemic use), HMG-Co-A reductase inhibitors (simvastatin, lovastatin), antipsychotics (pimozide, sertindole). See also the section “Interaction with other drugs”.

* Simultaneous use with the combination of lopinavir/ritonavir.

* Severe liver failure (Child-Pugh class C).

* Children under 6 years of age.

With caution

* Mild to moderate liver dysfunction (class A and B on the Child-Pugh scale)

* Allergy to sulfonamides

*Age over 65 years

* When taking drugs that are highly bound to alpha1-acid glycoprotein while taking drugs.

* In patients with chronic hepatitis (including chronic viral hepatitis B and C).

* In patients with hemophilia.

Manufacturer

Pharmasintez JSC, Russia